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Compound C108

Compound C108 是 GTPase 激活蛋白 SH3 结构域结合蛋白 2 (G3BP2) 的抑制剂。 Compound C108可用于乳腺肿瘤和食管鳞状细胞癌的研究。

CAS号

15533-09-2

分子式

C15H14N2O3

主要靶点

GTPase

仅限科研使用

Cat No : CM13767

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Synonyms

验证数据展示

  • CAS No.: 15533-09-2

    Compound C108
    CAS#: 15533-09-2

产品信息

Compound C108 is an inhibitor of GTPase-activating protein SH3 domain-binding protein 2 (G3BP2). Compound C108 can be used in studies about breast tumors and esophageal squamous cell carcinoma.

CAS号 15533-09-2
分子式 C15H14N2O3
主要靶点 GTPase
主要通路 G蛋白偶联受体
分子量 270.28
纯度 99.77%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

体内活性

In a mouse xenograft model of breast cancer, compound C108 (1 μM) reduces the proportion of tumor-initiating cells approximately 10-fold[1].

体外活性

In BT474 cells, Compound C108 (1 μM) shows anti-tumor activity[1]. In G3BP2 overexpressing KYSE410 cells and LINC01554 transfected KYSE30 cells, Compound C108 (4 μM) reduces the protein expression of G3BP2 and attenuates ESCC cell metastasis, migration and invasion[2].

溶解度

DMF:PBS(pH 7.2)(1:6):0.14 mg/mL,DMF:1 mg/mL,DMSO:22.5 mg/mL (83.2 mM),Sonification is recommended.

参考文献

1.Gupta N, et al. Stress granule-associated protein G3BP2 regulates breast tumor initiation. Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):1033-1038.
2.Zheng Y, et al. G3BP2 regulated by the lncRNA LINC01554 facilitates esophageal squamous cell carcinoma metastasis through stabilizing HDGF transcript. Oncogene. 2022 Jan;41(4):515-526.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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C1   V1   C2   V2