ChromoTek CoraLite® Plus 555-conjugated MSLN VHH

CL555-msln targets MSLN in FC and IF applications and shows reactivity with Human samples.

Host/Type

Alpaca VHH

Reactivity

Human

Applications

FC, IF

Conjugate

CoraLite® Plus 555 Fluorescent Dye

Cat No : CL555-msln

Synonyms

MSLN-Nanobody, MSLN-Single domain antibody (sdAb), CAK1 antigen, pre-pro-megakaryocyte-potentiating factor, MPF, MSLN, Mesothelin



Product Information

CL555-msln targets MSLN in FC and IF applications and shows reactivity with Human samples.

ApplicationsFC, IF
ReactivityHuman
ConjugateCoraLite® Plus 555 Fluorescent Dye
TypeNanobody
ClassRecombinant
HostAlpaca
AffinityPicomolar range, below the assay limit (biolayer interferometry)
Molecular Weight15.710 kDa
FormLiquid
Excitation/Emission Maxima Wavelengths554 nm / 570 nm
RRIDAB_3101942
Storage Buffer500 mM NaCl, 10 mM HEPES pH 7.0, 5 mM EDTA, 0.09% sodium azide
Storage ConditionStore at -20°C
BackgroundMesothelin (MSLN) is a 40kDa GPI-anchored surface glycoprotein that is expressed on pleural and peritoneal mesothelial cells, but not in other non-neoplastic tissues. The mesothelin gene encodes a 69-71kDa precursor protein that is processed to a 40kDa membrane-bound protein termed mesothelin and a 31kDa shed fragment called megakaryocyte-potentiating factor (MPF) that is released from the cell. Mesothelin is a tumor differentiation antigen present at low levels on a restricted set of normal adult tissues (e.g. mesothelium), and is expressed at high levels in mesotheliomas, as well as ovarian, pancreatic, and lung cancers. Mesothelin may be a new target for immunotherapy (PMID: 20922056, 18691948, 15217923).

Documentation

SDS
SDS-Immuno-Oncology VHHs