ChromoTek CoraLite® Plus 555-conjugated MSLN VHH
CL555-msln targets MSLN in FC and IF applications and shows reactivity with Human samples.
Host/Type
Alpaca VHH
Reactivity
Human
Applications
FC, IF
Conjugate
CoraLite® Plus 555 Fluorescent Dye
Cat No : CL555-msln
Synonyms
Validation Data Gallery
Product Information
CL555-msln targets MSLN in FC and IF applications and shows reactivity with Human samples.
Applications | FC, IF |
Reactivity | Human |
Conjugate | CoraLite® Plus 555 Fluorescent Dye |
Type | Nanobody |
Class | Recombinant |
Host | Alpaca |
Affinity | Picomolar range, below the assay limit (biolayer interferometry) |
Molecular Weight | 15.710 kDa |
Form | Liquid |
Excitation/Emission Maxima Wavelengths | 554 nm / 570 nm |
RRID | AB_3101942 |
Storage Buffer | 500 mM NaCl, 10 mM HEPES pH 7.0, 5 mM EDTA, 0.09% sodium azide |
Storage Condition | Store at -20°C |
Background | Mesothelin (MSLN) is a 40kDa GPI-anchored surface glycoprotein that is expressed on pleural and peritoneal mesothelial cells, but not in other non-neoplastic tissues. The mesothelin gene encodes a 69-71kDa precursor protein that is processed to a 40kDa membrane-bound protein termed mesothelin and a 31kDa shed fragment called megakaryocyte-potentiating factor (MPF) that is released from the cell. Mesothelin is a tumor differentiation antigen present at low levels on a restricted set of normal adult tissues (e.g. mesothelium), and is expressed at high levels in mesotheliomas, as well as ovarian, pancreatic, and lung cancers. Mesothelin may be a new target for immunotherapy (PMID: 20922056, 18691948, 15217923). |
Documentation
SDS |
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SDS-Immuno-Oncology VHHs |