DCC-Specific Monoclonal antibody, PBS Only
DCC-Specific Monoclonal Antibody for WB, Indirect ELISA
Host / Isotype
Mouse / IgG2a
Reactivity
Human, Mouse
Applications
WB, Indirect ELISA
Conjugate
Unconjugated
CloneNo.
2G4G4
验证数据展示
产品信息
67203-1-PBS targets DCC-Specific in WB, Indirect ELISA applications and shows reactivity with Human, Mouse samples.
| Tested Applications | WB, Indirect ELISA Application Description |
| Tested Reactivity | Human, Mouse |
| Immunogen | DCC-Specific fusion protein Ag20569 种属同源性预测 |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Full Name | deleted in colorectal carcinoma |
| Synonyms | Colorectal cancer suppressor, CRC18, CRCR1, DCC, DCC-Specific, IGDCC1, Netrin receptor DCC, Tumor suppressor protein DCC |
| Calculated Molecular Weight | 1447 aa, 158 kDa |
| Observed Molecular Weight | 180 kDa |
| GenBank Accession Number | NM_005215 |
| Gene Symbol | DCC |
| Gene ID (NCBI) | 1630 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | P43146 |
| Storage Buffer | PBS Only |
| Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
DCC, also named as IGDCC1, belongs to the immunoglobulin superfamily and DCC family. DCC is a receptor for netrin required for axon guidance. DCC plays a key role in the developing nervous system. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. DCC gene is a tumor suppressor gene. This antibody recognizes endogenous DCC with an apparent molecular weight of 180 kDa. As the predicted molecular mass of DCC is 158 kDa, the slower mobility is likely attributable to post-translational modification, perhaps by glycosylation at potential N-linked glycosylation sites (PMID: 7926722; 8044801).