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DK419

DK419 是一种具有口服活性的 Wnt/β-catenin 信号通路抑制剂，IC50 为 0.19 μM。 DK419 降低 Axin2、β-catenin、c-Myc、Cyclin D1 和 Survivin 的蛋白质水平。它还诱导 pAMPK 的产生。

CAS号

2102672-22-8

分子式

C16H8ClF6N3O

主要靶点

AMPK|Wnt/beta-catenin

仅限科研使用

Cat No : CM20783

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Synonyms

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  • CAS No.: 2102672-22-8

    DK419
    CAS#: 2102672-22-8

产品信息

DK419 is an orally active inhibitor of Wnt/β-catenin signaling, with an IC50 of 0.19 μM. DK419 decreases protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin.It also induces production of pAMPK.

CAS号 2102672-22-8
分子式 C16H8ClF6N3O
主要靶点 AMPK|Wnt/beta-catenin
主要通路 细胞骨架|干细胞|表观遗传|PI3K/Akt/mTOR信号通路
分子量 407.7
纯度 98.15%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

体内活性

DK419 inhibited the growth of patient derived CRC240 tumor explants in mice dosed orally[1].

体外活性

DK419 inhibited the growth of CRC tumor cells in vitro and had good plasma exposure when dosed orally[1].

溶解度

DMSO:80 mg/mL (196.22 mM),Sonification is recommended.

参考文献

1.Wang J, et al. Identification of DK419, a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth. Bioorg Med Chem. 2018 Nov 1;26(20):5435-5442.

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