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DNMT1 Monoclonal antibody, PBS Only

DNMT1 Monoclonal Antibody for WB,Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human, Mouse, Rat

Applications

WB,Indirect ELISA

Conjugate

Unconjugated

CloneNo.

2G5C5

Cat No : 68485-1-PBS

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Synonyms

AIM, CXXC9, DNA methyltransferase HsaI, DNA MTase HsaI, DNMT, DNMT1, FLJ16293, M.HsaI, MCMT

验证数据展示

  • WB analysis using 68485-1-Ig (same clone as 68485-1-PBS)

    WB analysis using 68485-1-Ig (same clone as 68485-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68485-1-Ig (DNMT1 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68485-1-PBS in a different storage buffer formulation.

产品信息

68485-1-PBS targets DNMT1 in WB, Indirect ELISA applications and shows reactivity with Human, Mouse, Rat samples.

Tested Applications WB,Indirect ELISA Application Description
Tested Reactivity Human, Mouse, Rat
Immunogen DNMT1 fusion protein Ag19116 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name DNA (cytosine-5-)-methyltransferase 1
Synonyms AIM, CXXC9, DNA methyltransferase HsaI, DNA MTase HsaI, DNMT, DNMT1, FLJ16293, M.HsaI, MCMT
Calculated Molecular Weight 1632 aa, 185 kDa
Observed Molecular Weight180-200 kDa
GenBank Accession NumberBC126227
Gene Symbol DNMT1
Gene ID (NCBI) 1786
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
UNIPROT IDP26358
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

背景介绍

DNA methylation is a major epigenetic modification that regulates gene expression. DNMT1, the maintenance DNA methylation enzyme, is the primary enzyme responsible for copying methylation patterns after DNA replication. DNMT1 is required for X chromosome inactivation, imprinting, genomic methylation and proper embryonic development. Overexpression of DNMT1 has been reported in various cancers. DNMT1 exists some isoforms with MW 184 kDa and 145 kDa. (PMID: 10753866)