DNMT1 Monoclonal antibody, PBS Only

DNMT1 Monoclonal Antibody for WB, Indirect ELISA
Cat No. 68485-1-PBS

产品说明书

CloneNo. 2G5C5

宿主/亚型

Mouse / IgG1

种属反应性

Human, Mouse, Rat

应用

WB, Indirect ELISA

AIM, CXXC9, DNA methyltransferase HsaI, DNA MTase HsaI, DNMT, DNMT1, FLJ16293, M.HsaI, MCMT

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -


产品信息

68485-1-PBS targets DNMT1 in WB, Indirect ELISA applications and shows reactivity with Human, Mouse, Rat samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 Human, Mouse, Rat
免疫原 DNMT1 fusion protein Ag19116 种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 DNA (cytosine-5-)-methyltransferase 1
别名 AIM, CXXC9, DNA methyltransferase HsaI, DNA MTase HsaI, DNMT, DNMT1, FLJ16293, M.HsaI, MCMT
计算分子量 1632 aa, 185 kDa
观测分子量180-200 kDa
GenBank蛋白编号BC126227
基因名称 DNMT1
Gene ID (NCBI) 1786
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein G purification
UNIPROT IDP26358
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

DNA methylation is a major epigenetic modification that regulates gene expression. DNMT1, the maintenance DNA methylation enzyme, is the primary enzyme responsible for copying methylation patterns after DNA replication. DNMT1 is required for X chromosome inactivation, imprinting, genomic methylation and proper embryonic development. Overexpression of DNMT1 has been reported in various cancers. DNMT1 exists some isoforms with MW 184 kDa and 145 kDa. (PMID: 10753866)

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