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Dymeclin Polyclonal antibody

Dymeclin Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, ELISA

Conjugate

Unconjugated

Cat no : 12001-1-AP

Print datasheet

Synonyms

DMC, DYM, Dymeclin, SMC

验证数据展示

  • WB analysis using 12001-1-AP

    WB analysis using 12001-1-AP

    Various lysates were subjected to SDS PAGE followed by western blot with 12001-1-AP (Dymeclin antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

经过测试的应用

Positive WB detected inHEK-293 cells, MCF-7 cells, mouse kidney tissue, mouse pancreas tissue

推荐稀释比

ApplicationDilution
Western Blot (WB)WB : 1:500-1:1000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

12001-1-AP targets Dymeclin in WB, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Applications WB, ELISA Application Description
Tested Reactivity human, mouse, rat
Immunogen Dymeclin fusion protein Ag2600 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name dymeclin
Synonyms DMC, DYM, Dymeclin, SMC
Calculated Molecular Weight 669 aa, 76 kDa
Observed Molecular Weight 76-80 kDa
GenBank Accession NumberBC001252
Gene Symbol Dymeclin
Gene ID (NCBI) 54808
RRIDAB_2246056
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ7RTS9
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

Human Dymeclin is encoded by DYM gene, defects in which are the cause of Dyggve-Melchior-Clausen syndrome (DMC) and Smith-McCort dysplasia (SMC). DMC is a rare autosomal recessive disorder characterized by short trunk dwarfism, microcephaly and psychomotor retardation, with cutaneous cells containing dilated rough endoplasmic reticulum, enlarged and aberrant vacuoles and numerous vesicles [PubMed: 12491225]. Distinct with features of DMS, SMC is a rare osteochondrodysplasia characterized by short limbs and trunk with barrel-shaped chest [PubMed: 19005420]. Dymeclin is a not a stably anchored transmembrane protein with a transmembrane domain, but it shuttles between Golgi and cytosol, which is necessary for correct organization of Golgi apparatus [PubMed: 18996921].

实验方案

Product Specific Protocols
WB protocol for Dymeclin antibody 12001-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols