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DYRK1A Polyclonal antibody

DYRK1A Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

Human

Applications

WB, ELISA

Conjugate

Unconjugated

Cat no : 28607-1-AP

Print datasheet

Synonyms

DYRK, DYRK1, DYRK1A, hMNB, HP86, MNB, MNBH

验证数据展示

  • WB analysis of HEK-293 using 28607-1-AP

    WB analysis of HEK-293 using 28607-1-AP

    HEK-293 cells were subjected to SDS PAGE followed by western blot with 28607-1-AP (DYRK1A antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

  • WB analysis of PC-3 using 28607-1-AP

    WB analysis of PC-3 using 28607-1-AP

    PC-3 cells were subjected to SDS PAGE followed by western blot with 28607-1-AP (DYRK1A antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

  • WB analysis using 28607-1-AP

    WB analysis using 28607-1-AP

    Various lysates were subjected to SDS PAGE followed by western blot with 28607-1-AP (DYRK1A antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours.

经过测试的应用

Positive WB detected inPC-3 cells, HEK-293 cells

推荐稀释比

ApplicationDilution
Western Blot (WB)WB : 1:1000-1:4000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

28607-1-AP targets DYRK1A in WB, ELISA applications and shows reactivity with Human samples.

Tested Applications WB, ELISA Application Description
Tested Reactivity Human
Immunogen DYRK1A fusion protein Ag29433 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
Synonyms DYRK, DYRK1, DYRK1A, hMNB, HP86, MNB, MNBH
Calculated Molecular Weight 86 kDa
Observed Molecular Weight70kDa, 85 kDa
GenBank Accession NumberNM_001396
Gene Symbol DYRK1A
Gene ID (NCBI) 1859
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ13627
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome.

实验方案

Product Specific Protocols
WB protocol for DYRK1A antibody 28607-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols