验证数据展示
经过测试的应用
| Positive WB detected in | rat testis tissue, mouse testis tissue |
| Positive IP detected in | mouse testis tissue |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Western Blot (WB) | WB : 1:1000-1:6000 |
| Immunoprecipitation (IP) | IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
14522-1-AP targets DYX1C1 in WB, IP, IF, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.
| 经测试应用 | WB, IP, ELISA Application Description |
| 文献引用应用 | WB, IP, IF, IHC |
| 经测试反应性 | human, mouse, rat |
| 文献引用反应性 | human, mouse |
| 免疫原 | DYX1C1 fusion protein Ag5997 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | dyslexia susceptibility 1 candidate 1 |
| 别名 | DYX1, DYX1C1, DYXC1, EKN1, RD |
| 计算分子量 | 49 kDa |
| 观测分子量 | 48 kDa |
| GenBank蛋白编号 | BC062564 |
| 基因名称 | DYX1C1 |
| Gene ID (NCBI) | 161582 |
| RRID | AB_2093955 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q8WXU2 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
DYX1C1 initially was described as the first candidate gene for developmental dyslexia. The protein contains three TPR motifs and one p23 domain, all commonly known for their protein-protein interactions. It also has been linked to neuronal migration. Recently it has been reported that the expression of DYX1C1 protein is lost in breast cancer and patients who have lost DYX1C1 expression have a poor overall survival,indicating that DYX1C1 is a potential prognostic biomarker in breast cancer.
实验方案
| Product Specific Protocols | |
|---|---|
| WB protocol for DYX1C1 antibody 14522-1-AP | Download protocol |
| IP protocol for DYX1C1 antibody 14522-1-AP | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
发表文章
| Species | Application | Title |
|---|---|---|
Nat Genet DYX1C1 is required for axonemal dynein assembly and ciliary motility.
| ||
Biol Psychiatry Molecular networks of DYX1C1 gene show connection to neuronal migration genes and cytoskeletal proteins. | ||
Mol Endocrinol The rs3743205 SNP is important for the regulation of the dyslexia candidate gene DYX1C1 by estrogen receptor β and DNA methylation. | ||
BMC Cancer The dyslexia candidate gene DYX1C1 is a potential marker of poor survival in breast cancer. | ||
BMC Mol Cell Biol Genetic and protein interaction studies between the ciliary dyslexia candidate genes DYX1C1 and DCDC2 |
