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Denifanstat

Denifanstat (FASN-IN-2) 是一种口服具有活性的选择性 FASN 抑制剂，IC50=0.052 μM，EC50=0.072 μM。它有用于脂肪肝和癌症的研究潜力。

CAS号

1399177-37-7

分子式

C27H29N5O

主要靶点

Fatty Acid Synthase

仅限科研使用

Cat No : CM15445

Print datasheet

Synonyms

TVB2640|TVB-2640|FASN-IN-2

验证数据展示

  • CAS No.: 1399177-37-7

    Denifanstat
    CAS#: 1399177-37-7

产品信息

Denifanstat (FASN-IN-2) is a Fatty Acid Synthase (FASN) inhibitor(IC50 of 0.052 μM and an EC50 of 0.072 μM),with potential antineoplastic activity.

CAS号 1399177-37-7
分子式 C27H29N5O
主要靶点 Fatty Acid Synthase
主要通路 代谢
分子量 439.55
纯度 99.44%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 TVB2640|TVB-2640|FASN-IN-2

靶点活性

FASN:0.052 μM

体外活性

TVB-2640 is an orally bioavailable fatty acid synthase (FASN) inhibitor, with potential antineoplastic activity. Upon administration, TVB-2640 binds to and blocks FASN, which prevents the synthesis of palmitate needed for tumor cell growth and survival. This leads to a reduction in cell signaling, an induction of tumor cell apoptosis and the inhibition of cell proliferation in susceptible tumor cells. FASN, an enzyme responsible for the de novo synthesis of palmitic acid, is overexpressed in tumor cells and plays a key role in tumor metabolism, lipid signaling, tumor cell survival and drug resistance; tumor cells are dependent on increased fatty acid production for their enhanced metabolic needs and rapid growth. Check for active clinical trials or closed clinical trials using this agent.

溶解度

DMSO:250 mg/mL (568.76 mM)

参考文献

1.Johan D., et al. Heterocyclic modulators of lipid synthesis. WO2012122391A1.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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C1   V1   C2   V2