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Dihydrocoumarin

Dihydrocoumarin (melilotin) 是在草木犀中发现的一种天然产物。它是酵母 Sir2p 抑制剂，还抑制人 SIRT1和SIRT2，IC50分别为 208 和 295 μM。

CAS号

119-84-6

分子式

C9H8O2

主要靶点

Sirtuin

仅限科研使用

Cat No : CM00209

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Synonyms

二氢香豆素；氢化肉桂酸内酯、1,2-苯并二氢吡喃酮、二氢色满酮、二羟基香豆素;苯并二氢吡喃酮;二氢香豆酯、二氢香兰素|Hydrocoumarin|Chroman-2-one|二氢香豆素|melilotin|2-chromanone|3,4-dihydrocoumarin

验证数据展示

  • CAS No.: 119-84-6

    Dihydrocoumarin
    CAS#: 119-84-6

产品信息

Dihydrocoumarin is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 and SIRT2 with IC50s of 208 μM and 295 μM, respectively.

CAS号 119-84-6
分子式 C9H8O2
主要靶点 Sirtuin
主要通路 DNA损伤和修复|表观遗传
分子量 148.16
纯度 99.19%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 二氢香豆素；氢化肉桂酸内酯、1,2-苯并二氢吡喃酮、二氢色满酮、二羟基香豆素;苯并二氢吡喃酮;二氢香豆酯、二氢香兰素|Hydrocoumarin|Chroman-2-one|二氢香豆素|melilotin|2-chromanone|3,4-dihydrocoumarin

靶点活性

human SIRT1:208 μM|hμMan SIRT2:295 μM

溶解度

DMSO:11 mg/mL (74.24 mM)

参考文献

1.Podyma W, Baczek K, Angielczyk M, et al. The influence of shading on the yield and quality of southern sweet-grass (Hierochloë  australis (Schrad.) Roem. & Schult.) raw material.[J]. Herba Polonica, 2010, 56(4):14-19.

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