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Dimesna

Dimesna (BNP-7787) 是一种二硫代乙烷磺酸盐的合成衍生物，具有泌尿保护特性。

CAS号

16208-51-8

分子式

C4H8Na2O6S4

主要靶点

Others

仅限科研使用

Cat No : CM05506

Print datasheet

Synonyms

BNP-7787|地美司钠

验证数据展示

  • CAS No.: 16208-51-8

    Dimesna
    CAS#: 16208-51-8

产品信息

Dimesna is a synthetic derivative of dithio-ethane sulfonate with uroprotective properties.

CAS号 16208-51-8
分子式 C4H8Na2O6S4
主要靶点 Others
主要通路 其他
分子量 326.34
纯度 99.76%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 BNP-7787|地美司钠

体内活性

Dimesna能够调节紫杉醇诱导的MTP超聚合,而Dimesna的体内代谢产物mesna,可防止顺铂诱导的MTP失活。肾有机阴离子转运蛋白OAT1（KM=636 μM）,OAT3（ KM=390 μM ）和OAT4（KM=590 μM）能够特异性的结合Dimesna。

体外活性

在大鼠膀胱癌中,Dimesna可以以剂量依赖方式降低环磷酰胺.

溶解度

DMSO:68 mg/mL (208.37 mM),Sonification/heating is recommended.

参考文献

1.Parker AR, et al. Mol, Cancer Ther, 2010, 9(9), 2558-2567.
2.Hausheer FH, et al. Cancer Chemother Pharmacol, 2010, 65(5), 941-951.
3.Cutler MJ, et al. J Clin Pharmacol, 2012, 52(4), 530-542.
4.Habs MR, et al. Cancer, 1983, 51(4), 606-609.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2