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Doxapram hydrochloride hydrate

Doxapram hydrochloride hydrate (Doxapram HCl) 是 TASK-1，TASK-3和 TASK-1/TASK-3异二聚体通道的抑制剂，EC50分别为410 nM，37 μM 和9 μM。

CAS号

7081-53-0

分子式

C24H33ClN2O3（C24H30N2O2·ClH·H2O）

主要靶点

Potassium Channel

仅限科研使用

Cat No : CM00946

Print datasheet

Synonyms

多沙普仑盐酸一水合物|Doxapram hydrochloride monohydrate|盐酸多沙普仑|Doxapram HCl

验证数据展示

  • CAS No.: 7081-53-0

    Doxapram hydrochloride hydrate
    CAS#: 7081-53-0

产品信息

Doxapram hydrochloride hydrate (Doxapram HCl) inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively.

CAS号 7081-53-0
分子式 C24H33ClN2O3（C24H30N2O2·ClH·H2O）
主要靶点 Potassium Channel
主要通路 离子通道
分子量 432.99
纯度 99.64%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 多沙普仑盐酸一水合物|Doxapram hydrochloride monohydrate|盐酸多沙普仑|Doxapram HCl

靶点活性

TASK-3:37 μM(EC50)|TASK-1:410 nM(EC50)|TASK-1 heterodimeric channel:9 μM(EC50)

溶解度

H2O:23 mg/mL (53.1 mM),Ethanol:2 mg/mL (4.61 mM),DMSO:81 mg/mL (187.1 mM)

参考文献

1.Cotten JF, et al. Anesth Analg, 2006, 102(3), 779-785.
2.Robson RH, et al. Br J Clin Pharmacol, 1979, 7(1), 81–87.
3.Okuyama K, et al. Anesth Analg, 2003, 97(3), 759-762.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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C1   V1   C2   V2