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Dynarrestin

Dynarrestin 是一种细胞质动力蛋白 1 和 2的氨基噻唑抑制剂。它能够快速的、可逆的抑制动力蛋白 1 驱动的微管在体外滑动和细胞内动力蛋白 1 和 2 依赖性过程，且不影响 ATP 水解和干扰纤毛发生。它可抑制神经元前体和肿瘤细胞的刺猬因子依赖性增殖。

CAS号

2222768-84-3

分子式

C22H23F2N3O2S

主要靶点

Hedgehog/Smoothened

仅限科研使用

Cat No : CM03625

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Synonyms

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  • CAS No.: 2222768-84-3

    Dynarrestin
    CAS#: 2222768-84-3

产品信息

Dynarrestin is a cytoplasmic dynein 1 and 2 aminothiazole inhibitor that reversibly inhibits dynein 1-driven microtubule sliding in vitro and intracellular dynein 1 and 2-dependent processes without affecting ATP hydrolysis and interfering with ciliogenesis .

CAS号 2222768-84-3
分子式 C22H23F2N3O2S
主要靶点 Hedgehog/Smoothened
主要通路 干细胞|G蛋白偶联受体
分子量 431.5
纯度 99.49%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

溶解度

DMSO:80mg/mL (185.40mM),Sonification is recommended.

参考文献

1.Höing S, et al. Dynarrestin, a Novel Inhibitor of Cytoplasmic Dynein. Cell Chem Biol. 2018 Apr 19;25(4):357-369.e6.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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