验证数据展示
发表文章中的应用
| IF | See 1 publications below |
产品信息
17943-1-AP targets ELA2 in IF, ELISA applications and shows reactivity with human, mouse, rat samples.
| 经测试应用 | ELISA Application Description |
| 文献引用应用 | IF |
| 经测试反应性 | human, mouse, rat |
| 文献引用反应性 | bovine |
| 免疫原 | ELA2 fusion protein Ag12372 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | elastase 2, neutrophil |
| 别名 | Bone marrow serine protease, ELA2, ELANE, Elastase 2, elastase 2, neutrophil, GE, HLE, HNE, Human leukocyte elastase, Medullasin, NE, Neutrophil elastase, PMN E, PMN elastase |
| 计算分子量 | 267 aa, 29 kDa |
| GenBank蛋白编号 | BC074816 |
| 基因名称 | ELA2 |
| Gene ID (NCBI) | 1991 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | P08246 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
ELA2(Neutrophil elastase) is also named as ELAL, NE, HLE, HNE, PMN-E, SERP1, GE, ELANE and belongs to the peptidase S1 family. It is a 33-kDa enzyme with several isoforms that differ in their extent of glycosylation(PMID:12223222). Human neutrophil elastase (HNE) is a serine protease with potent proteolytic activity (3), which is reported to cause mucin secretion (degranulation)(PMID:12169572). It may contribute to the directed migration of leukocytes into flamed postcapillary venules in addition to contributing to the process of tissue emigration(PMID:9683424). The full length protein has a signal peptide,propeptide and three glycosylation sites.
发表文章
| Species | Application | Title |
|---|---|---|
Biol Trace Elem Res Effect of Copper, Zinc, and Selenium on the Formation of Bovine Neutrophil Extracellular Traps. | ||
Cell Death Discov Neutrophil extracellular traps induced by VP1 contribute to pulmonary edema during EV71 infection. |