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EUK-134

EUK-134 是合成的超氧化物歧化酶和过氧化氢酶模拟物，可保护大鼠肾脏免受缺血再灌注引起的损伤。它作用于 H9C2 细胞，降低NF-κB 表达、MDA 水平和蛋白质羰基化。它是具有过氧化氢酶活性的超氧化物歧化酶 (SOD) 模拟物 (SODm)。它是保护有丝分裂的抗氧化剂。

CAS号

81065-76-1

分子式

C18H18ClMnN2O4

主要靶点

Beta Amyloid

仅限科研使用

Cat No : CM02696

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Synonyms

EUK 134|乙基双亚氨基甲基愈创木酚锰氯化物

验证数据展示

  • CAS No.: 81065-76-1

    EUK-134
    CAS#: 81065-76-1

产品信息

EUK-134, a synthetic superoxide dismutase (SOD)/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril.

CAS号 81065-76-1
分子式 C18H18ClMnN2O4
主要靶点 Beta Amyloid
主要通路 神经科学
分子量 416.74
纯度 99.78%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 EUK 134|乙基双亚氨基甲基愈创木酚锰氯化物

体内活性

EUK 134 (2.5 mg/kg), in a middle cerebral artery occlusion model, significantly reduces brain infarct size, and apparently prevents further infarct growth. [1] EUK-134 prevents oxidative stress and attenuates rat brain damage induced by systemic administration of systemic kainic acid (KA). [5]

体外活性

EUK 134 shows potent catalase and SOD activities, and protects human fibroblasts against cytotoxicity by glucose and glucose oxidase. [1] EUK 134 (20 μM) prevents Aβ-induced microglial proliferation in vitro. [2] In SK-N-MC cells, EUK134 protects neuronal cells against H(2)O(2) toxicity by attenuating oxidative stress through inhibition of MAPK pathway, and also results in decreased expression of pro-apoptotic genes p53 and Bax as well as enhanced expression of anti-apoptotic Bcl-2 gene. [3] EUK 134 significantly inhibits amyloid formation at two molar ratios of 1:1 and 5:1 (drugs to protein). [4]

溶解度

Ethanol:<1 mg/mL,H2O:11 mg/mL (26.4 mM),DMSO:77 mg/mL (184.8 mM)

参考文献

1.Baker K, et al. J Pharmacol Exp Ther. 1998, 284(1), 215-221.
2.Jekabsone A, et al. J Neuroinflammation. 2006, 3, 24.
3.Mohammadi M, et al. Basic Clin Pharmacol Toxicol. 2011, 108(6), 378-384.
4.Bahramikia S, et al. Eur J Pharmacol. 2013, 707(1-3), 17-25.
5.Rong Y, et al. Proc Natl Acad Sci U S A. 1999, 96(17), 19897-19902.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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