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EXOSC2 Monoclonal antibody, PBS Only

EXOSC2 Monoclonal Antibody for WB, IHC, IF/ICC, Indirect ELISA

Host / Isotype

Mouse / IgG2a

Reactivity

human

Applications

WB, IHC, IF/ICC, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

1G8B1

Cat no : 66099-1-PBS

Print datasheet

Synonyms

EXOSC2, exosome component 2, hRrp4p, p7, RRP4, Rrp4p

验证数据展示

  • IHC staining of human skin cancer using 66099-1-Ig (same clone as 66099-1-PBS)

    IHC staining of human skin cancer using 66099-1-Ig (same clone as 66099-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human skin cancer slide using 66099-1-Ig (EXOSC2 Antibody) at dilution of 1:50. This data was developed using the same antibody clone with 66099-1-PBS in a different storage buffer formulation.

  • IHC staining of human liver using 66099-1-Ig (same clone as 66099-1-PBS)

    IHC staining of human liver using 66099-1-Ig (same clone as 66099-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver slide using 66099-1-Ig (EXOSC2 Antibody) at dilution of 1:50. This data was developed using the same antibody clone with 66099-1-PBS in a different storage buffer formulation.

  • IF Staining of HepG2 using 66099-1-Ig (same clone as 66099-1-PBS)

    IF Staining of HepG2 using 66099-1-Ig (same clone as 66099-1-PBS)

    Immunofluorescent analysis of () fixed HepG2 cells using 66099-1-Ig (EXOSC2 antibody) at dilution of 1:25. This data was developed using the same antibody clone with 66099-1-PBS in a different storage buffer formulation.

  • WB analysis using 66099-1-Ig (same clone as 66099-1-PBS)

    WB analysis using 66099-1-Ig (same clone as 66099-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 66099-1-Ig (EXOSC2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. The membrane was stripped and reblotted with HRP-conjugated Alpha Tubulin Monoclonal antibody (HRP-66031) as loading control. This data was developed using the same antibody clone with 66099-1-PBS in a different storage buffer formulation.

产品信息

66099-1-PBS targets EXOSC2 in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

Tested Applications WB, IHC, IF/ICC, Indirect ELISA Application Description
Tested Reactivity human
Immunogen EXOSC2 fusion protein Ag7003 种属同源性预测
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Full Name exosome component 2
Synonyms EXOSC2, exosome component 2, hRrp4p, p7, RRP4, Rrp4p
Calculated Molecular Weight 33 kDa
Observed Molecular Weight 33 kDa
GenBank Accession NumberBC000747
Gene Symbol EXOSC2
Gene ID (NCBI) 23404
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDQ13868
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snoRNA and snRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs [PMID:15346807]. EXOSC2 is a non-catalytic component of the RNA exosome complex that has 3'->5' exoribonuclease activity and involves in a multitude of cellular RNA processing and degradation events [PMID: 17545563].