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FBXO22 Monoclonal antibody, PBS Only

FBXO22 Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

4B8A12

Cat no : 68650-1-PBS

Print datasheet

Synonyms

F box only protein 22, F box protein 22, F box protein FBX22p44, FBX22, FBXO22, FISTC1, FLJ13986

验证数据展示

  • WB analysis using 68650-1-Ig (same clone as 68650-1-PBS)

    WB analysis using 68650-1-Ig (same clone as 68650-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68650-1-Ig (FBXO22 antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68650-1-PBS in a different storage buffer formulation.

产品信息

68650-1-PBS targets FBXO22 in WB, Indirect ELISA applications and shows reactivity with Human samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity Human
Immunogen FBXO22 fusion protein Ag5294 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name F-box protein 22
Synonyms F box only protein 22, F box protein 22, F box protein FBX22p44, FBX22, FBXO22, FISTC1, FLJ13986
Calculated Molecular Weight 403 aa, 45 kDa
Observed Molecular Weight45 kDa
GenBank Accession NumberBC039024
Gene Symbol FBXO22
Gene ID (NCBI) 26263
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
UNIPROT IDQ8NEZ5
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

FBXO22, also named as FBX22, is a substrate-recognition of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. FBXO22 is a key regulator of senescence induction through ubiquitylation of p53 for degradation. FBXO22 also acts as a molecular switch for the antagonistic and agonistic actions of selective estrogen receptor modulators (SERM) and determines the sensitivity of breast cancer to SERM by ubiquitylating KDM4B complexed with unliganded or SERMs‐bound estrogen receptor (ER). (PMID: 32536008, PMID: 32249768)