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验证数据展示

  • WB analysis of Jurkat using 68650-1-Ig (same clone as 68650-1-PBS)

    WB analysis of Jurkat using 68650-1-Ig (same clone as 68650-1-PBS)

    WB result of FBXO22 antibody (68650-1-Ig; 1:4000; room temperature for 1.5 hours) with wild-type and FBXO22 knockout Jurkat cells. This data was developed using the same antibody clone with 68650-1-PBS in a different storage buffer formulation.

  • WB analysis using 68650-1-Ig (same clone as 68650-1-PBS)

    WB analysis using 68650-1-Ig (same clone as 68650-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68650-1-Ig (FBXO22 antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68650-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO验证

FBXO22 Monoclonal antibody, PBS Only

FBXO22 Monoclonal Antibody for WB, Indirect ELISA
Cat No. 68650-1-PBS

产品说明书

CloneNo. 4B8A12

宿主/亚型

Mouse / IgG1

种属反应性

human

应用

WB, Indirect ELISA

别名

FBX22, F-box protein FBX22p44, F-box only protein 22, F box protein 22, F box only protein 22

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

68650-1-PBS targets FBXO22 in WB, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 human
免疫原 FBXO22 fusion protein Ag5294 种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 F-box protein 22
别名 FBX22, F-box protein FBX22p44, F-box only protein 22, F box protein 22, F box only protein 22
计算分子量 403 aa, 45 kDa
观测分子量45 kDa
GenBank蛋白编号BC039024
基因名称 FBXO22
Gene ID (NCBI) 26263
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein G purification
UNIPROT IDQ8NEZ5
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

FBXO22, also named as FBX22, is a substrate-recognition of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. FBXO22 is a key regulator of senescence induction through ubiquitylation of p53 for degradation. FBXO22 also acts as a molecular switch for the antagonistic and agonistic actions of selective estrogen receptor modulators (SERM) and determines the sensitivity of breast cancer to SERM by ubiquitylating KDM4B complexed with unliganded or SERMs‐bound estrogen receptor (ER). (PMID: 32536008, PMID: 32249768)