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Host
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Species Reactivity
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Species Reactivity
0
Conjugate
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验证数据展示

  • WB analysis using 83509-5-RR (same clone as 83509-5-PBS)

    WB analysis using 83509-5-RR (same clone as 83509-5-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 83509-5-RR (FBXO38 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83509-5-PBS in a different storage buffer formulation.

  • IF Staining of HepG2 using 83509-5-RR (same clone as 83509-5-PBS)

    IF Staining of HepG2 using 83509-5-RR (same clone as 83509-5-PBS)

    Immunofluorescent analysis of (4% PFA) fixed HepG2 cells using FBXO38 antibody (83509-5-RR, Clone: 240513A4 ) at dilution of 1:250 and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L) (SA00013-1), CL594-Phalloidin (red). This data was developed using the same antibody clone with 83509-5-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 83509-5-RR

    Affinity and Kinetic Characterization of 83509-5-RR

    Biolayer interferometry (BLl) kinetic assays of 83509-5-RR against Human FBXO38 were performed. The affinity constant is 0.233 nM.

FBXO38 Recombinant antibody, PBS Only

FBXO38 Uni-rAbTM Recombinant Antibody for WB, IF/ICC, ELISA
Cat No. 83509-5-PBS

产品说明书

CloneNo. 240513A4

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IF/ICC, ELISA

别名

SP329, MOKA, Fbx38, F box protein 38, F box only protein 38

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

83509-5-PBS targets FBXO38 in WB, IF/ICC, ELISA applications and shows reactivity with human samples.

经测试应用 WB, IF/ICC, ELISA Application Description
经测试反应性 human
免疫原 FBXO38 fusion protein Ag35444 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 F-box protein 38
别名 SP329, MOKA, Fbx38, F box protein 38, F box only protein 38
计算分子量134kDa，1188aa
观测分子量125kDa, 140 kDa, 150kDa
GenBank蛋白编号XM_005268513.1
基因名称 FBXO38
Gene ID (NCBI) 81545
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDQ6PIJ6
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

F-box-containing protein 38 (FBXO38), a member of the F-box family, was initially discovered as a co-activator of the transcription factor Krüppel-like factor 7 (KLF7) (PMID: 14729953). FBXO38 acts as a substrate-binding receptor for multi-subunit ubiquitin ligase SKP1-CUL1-FBXO38 (PMID: 35769260) . FBXO38 is an E3 ligase of PD-1 that mediates Lys48-linked poly-ubiquitination and subsequent proteasome degradation (PMID: 30487606).