验证数据展示
产品信息
10657-1-PBS targets FBXW4 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.
经测试应用 | WB, IHC, Indirect ELISA Application Description |
经测试反应性 | human, mouse |
免疫原 | FBXW4 fusion protein Ag1047 种属同源性预测 |
宿主/亚型 | Rabbit / IgG |
抗体类别 | Polyclonal |
产品类型 | Antibody |
全称 | F-box and WD repeat domain containing 4 |
别名 | |
计算分子量 | 46 kDa |
观测分子量 | 50 kDa |
GenBank蛋白编号 | BC007380 |
基因名称 | FBXW4 |
Gene ID (NCBI) | 6468 |
RRID | AB_2102754 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Antigen affinity purification |
UNIPROT ID | P57775 |
储存缓冲液 | PBS only , pH 7.3 |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins, and they are a family of eukaryotic proteins characterized by an approximately 40 amino acid motif. SCF complex, a class of ubiquitin ligases, consists of invariable components, Skp1 and Cullin, and variable components of F-box proteins, which have a primary role in determining substrate specificity. FBXW4, also known as SHFM3, encodes F-box and WD-40 domain-containing protein 4. Defects in SHFM3 are a cause of split-hand/foot malformation type 3 (SHFM3), an autosomal dominant disorder characterized by hypoplasia/aplasia of the central digits with fusion of the remaining digits.