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FDFT1 Recombinant antibody, PBS Only

FDFT1 Recombinant Antibody for WB,Indirect ELISA,FC

Host / Isotype

Rabbit / IgG

Reactivity

Human, mouse

Applications

WB,Indirect ELISA,FC

Conjugate

Unconjugated

CloneNo.

230362C10

Cat No : 83020-1-PBS

Print datasheet

Synonyms

DGPT, ERG9, FDFT1, FPP:FPP farnesyltransferase, SQS, Squalene synthase, SS

验证数据展示

  • WB analysis using 83020-1-RR (same clone as 83020-1-PBS)

    WB analysis using 83020-1-RR (same clone as 83020-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 83020-1-RR (FDFT1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83020-1-PBS in a different storage buffer formulation.

  • FC experiment of U2OS using 83020-1-RR (same clone as 83020-1-PBS)

    FC experiment of U2OS using 83020-1-RR (same clone as 83020-1-PBS)

    1x10^6 U2OS cells were intracellularly stained with 0.25 ug Anti-Human FDFT1 (83020-1-RR, Clone:230362C10) and APC-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L)(red), or 0.25 ug Rabbit IgG control Rabbit PolyAb (30000-0-AP) (blue). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). This data was developed using the same antibody clone with 83020-1-PBS in a different storage buffer formulation.

产品信息

83020-1-PBS targets FDFT1 in WB, FC, Indirect ELISA applications and shows reactivity with Human, mouse samples.

Tested Applications WB,Indirect ELISA,FC Application Description
Tested Reactivity Human, mouse
Immunogen FDFT1 fusion protein Ag3743 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name farnesyl-diphosphate farnesyltransferase 1
Synonyms DGPT, ERG9, FDFT1, FPP:FPP farnesyltransferase, SQS, Squalene synthase, SS
Calculated Molecular Weight 417 aa, 48 kDa
Observed Molecular Weight48 kDa
GenBank Accession NumberBC029641
Gene Symbol FDFT1
Gene ID (NCBI) 2222
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP37268
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

背景介绍

SQS (Squalene synthase), also known as Farnesyl-diphosphate farnesyltransferase 1 (FDFT1) is a gene that encodes the membrane-associated enzyme squalene synthase, which is the first specific enzyme in cholesterol biosynthesis. FDFT1 is highly expressed in liver, lung, prostate, breast, ovary, bladder, cervix, thyroid, and esophageal cancers, while in colorectal, colon, testicular, uterine, pancreas, and kidney tumors, its expression is downregulated (PMID: 35093030). FDFT1 is a key downstream target of the fasting response and may be involved in CRC cell glucose metabolism (PMID: 32313017).