验证数据展示
产品信息
13042-1-PBS targets FGFR2 in IHC, IF/ICC, FC (Intra), Indirect ELISA applications and shows reactivity with human samples.
Tested Applications | IHC, IF/ICC, FC (Intra), Indirect ELISA Application Description |
Tested Reactivity | human |
Immunogen | FGFR2 fusion protein Ag3701 种属同源性预测 |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Full Name | fibroblast growth factor receptor 2 |
Synonyms | EC:2.7.10.1, CFD1, CEK3, CD332, BFR 1 |
Calculated Molecular Weight | 709 aa, 79 kDa |
Observed Molecular Weight | |
GenBank Accession Number | BC039243 |
Gene Symbol | FGFR2 |
Gene ID (NCBI) | 2263 |
RRID | AB_10642943 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen affinity purification |
UNIPROT ID | P21802 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
FGFR2 (Fibroblast growth factor receptor 2) is a tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration, and apoptosis. Ligand binding leads to the activation of several signaling pathways, such as RAS, MAPK1/ERK2, MAPK3/ERK1, and the MAP Kinase signaling pathway, as well as the AKT1 signaling pathway. Mutations in the gene of FGFR2 are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. This polyclonal antibody raised against 358-704aa of human FGFR2 can cross-react with other members of the FGFR family.