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验证数据展示

  • IHC staining of human breast cancer using 55358-1-AP

    IHC staining of human breast cancer using 55358-1-AP

    Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 55358-1-AP (FGFR3 antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

    Ready-to-use IHC kits available with FGFR3 antibody included
  • IHC staining of human colon cancer using 55358-1-AP

    IHC staining of human colon cancer using 55358-1-AP

    Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 55358-1-AP (FGFR3 antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

    Ready-to-use IHC kits available with FGFR3 antibody included
  • IHC staining of human lung cancer using 55358-1-AP

    IHC staining of human lung cancer using 55358-1-AP

    Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 55358-1-AP (FGFR3 antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

    Ready-to-use IHC kits available with FGFR3 antibody included
  • IHC staining of rat testis using 55358-1-AP

    IHC staining of rat testis using 55358-1-AP

    Immunohistochemical analysis of paraffin-embedded rat testis tissue slide using 55358-1-AP (FGFR3 antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

    Ready-to-use IHC kits available with FGFR3 antibody included
  • IHC staining of mouse kidney using 55358-1-AP

    IHC staining of mouse kidney using 55358-1-AP

    Immunohistochemical analysis of paraffin-embedded mouse kidney tissue slide using 55358-1-AP (FGFR3 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

    Ready-to-use IHC kits available with FGFR3 antibody included

FGFR3 Polyclonal antibody

FGFR3 Polyclonal Antibody for IHC, ELISA
Cat No. 55358-1-AP

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

IHC, ELISA

别名

ACH, CD333, CEK2, FGFR 3, FGFR3, HSFGFR3EX, JTK4

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  Unconjugated
Unconjugated
规格: 

-/ -

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经过测试的应用

Positive IHC detected inhuman breast cancer tissue, mouse kidney tissue, rat testis tissue, human lung cancer tissue, human colon cancer tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Planning an IHC experiment? We recommend our IHCeasy FGFR3 Ready-To-Use IHC Kit. FGFR3 primary antibody included.

推荐稀释比

应用推荐稀释比
Immunohistochemistry (IHC)IHC : 1:500-1:2000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

55358-1-AP targets FGFR3 in IHC, ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 IHC, ELISA Application Description
经测试反应性 human, mouse, rat
免疫原 Peptide 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 fibroblast growth factor receptor 3
别名 ACH, CD333, CEK2, FGFR 3, FGFR3, HSFGFR3EX, JTK4
计算分子量 88 kDa
GenBank蛋白编号NM_000142
基因名称 FGFR3
Gene ID (NCBI) 2261
RRIDAB_3086442
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDP22607
储存缓冲液 PBS with 0.02% sodium azide and 50% glycerol , pH 7.3
储存条件Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

Fibroblast growth factors (FGFs) are polypeptide growth factors involved in a variety of activities including mitogenesis, angiogenesis, and wound healing (PMID: 1847508). The human FGF receptor family, a subfamily of receptor tyrosine kinases (RTKs), comprises of four family members-FGFR1, FGFR2, FGFR3, and FGFR4 (PMID: 23900974). Each receptor contains an extracellular domain with either two or three immunoglobulin-like domains, a transmembrane domain, and a cytoplasmic tyrosine kinase domain. FGFR3 binds acidic and basic fibroblast GH and plays a role in bone development and maintenance. Mutations in the FGFR3 gene lead to craniosynostosis and multiple types of skeletal dysplasia. Due to frequent mutations in certain cancers, the FGFR3 gene has also been associated with tumor progression.

实验方案

Product Specific Protocols
IHC protocol for FGFR3 antibody 55358-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols