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FGFR4 Monoclonal antibody, PBS Only

FGFR4 Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

1A2B5

Cat no : 67800-1-PBS

Print datasheet

Synonyms

CD334, FGFR 4, FGFR4, JTK2, TKF

验证数据展示

  • WB analysis using 67800-1-Ig (same clone as 67800-1-PBS)

    WB analysis using 67800-1-Ig (same clone as 67800-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67800-1-Ig (FGFR4 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67800-1-PBS in a different storage buffer formulation.

产品信息

67800-1-PBS targets FGFR4 in WB, Indirect ELISA applications and shows reactivity with Human samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity Human
Immunogen FGFR4 fusion protein Ag17041 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name fibroblast growth factor receptor 4
Synonyms CD334, FGFR 4, FGFR4, JTK2, TKF
Calculated Molecular Weight 88 kDa
Observed Molecular Weight100-110 kDa
GenBank Accession NumberBC011847
Gene Symbol FGFR4
Gene ID (NCBI) 2264
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
UNIPROT IDP22455
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Fibroblast growth factor receptor 4 (FGFR4) is a member of a highly conserved tyrosine kinase family, along with FGFR1-3. This family consists of an intracellular tyrosine kinase domain, a single transmembrane domain, and extracellular ligand binding domains (PMID:32492514). FGFR4 is the predominant FGFR isoform present in human hepatocytes. FGFR4 has been proposed to play a role in the observed induction of hepatocyte proliferation and carcinogenesis by FGF19; however, contradicting evidence proposing a protective role for FGFR4 in suppressing hepatoma progression has also been proposed(PMID:20018895). While the role of FGFR4 in cancer remains to be fully elucidated, several findings suggest that this receptor may be an important player in Hepatocellular carcinoma (HCC) development and/or progression(PMID:10336501).