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FLNC Polyclonal antibody, PBS Only

FLNC Polyclonal Antibody for WB, IHC, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IHC, Indirect ELISA

Conjugate

Unconjugated

Cat no : 28492-1-PBS

Print datasheet

Synonyms

FLN2, FilaminC, Filamin C, Filamin 2, ABPL

验证数据展示

  • WB analysis of SGC-7901 using 28492-1-AP (same clone as 28492-1-PBS)

    WB analysis of SGC-7901 using 28492-1-AP (same clone as 28492-1-PBS)

    SGC-7901 cells were subjected to SDS PAGE followed by western blot with 28492-1-AP (filamin-c antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 28492-1-PBS in a different storage buffer formulation.

  • IHC staining of human colon using 28492-1-AP (same clone as 28492-1-PBS)

    IHC staining of human colon using 28492-1-AP (same clone as 28492-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon slide using 28492-1-AP (FLNC antibody) at dilution of 1:200 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 28492-1-PBS in a different storage buffer formulation.

产品信息

28492-1-PBS targets FLNC in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

Tested Applications WB, IHC, Indirect ELISA Application Description
Tested Reactivity human
Immunogen FLNC fusion protein Ag29328 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name filamin C, gamma (actin binding protein 280)
Synonyms FLN2, FilaminC, Filamin C, Filamin 2, ABPL
Calculated Molecular Weight 291 kDa
Observed Molecular Weight 280-300 kDa
GenBank Accession NumberNM_001458
Gene Symbol FLNC
Gene ID (NCBI) 2318
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ14315
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Filamin C (FLNC; also known as γ-FLN; ABP-L; FLN2), a muscle-specific filamin and a large actin-cross-linking protein. Human filamins are ~280 kDa homodimers, each monomer consisting of an N-terminal actin-binding domain followed by 24 immunoglobulin (Ig)-like domains (d1 to d24), the last of which mediates dimerization. FLNC is specifically expressed in cardiomyocytes and skeletal myocytes and is involved in the maintenance of structural integrity. High filamin C associated with better prognosis of prostate cancer, leukemia and breast cancer patients. ( PMID: 25577646, PMID: 30867563, PMID: 31131323)