验证数据展示
产品信息
82671-1-PBS targets FNDC5 in WB, IHC, Indirect ELISA applications and shows reactivity with Human, mouse, rat, pig samples.
经测试应用 | WB, IHC, Indirect ELISA Application Description |
经测试反应性 | Human, mouse, rat, pig |
免疫原 | FNDC5 fusion protein Ag29714 种属同源性预测 |
宿主/亚型 | Rabbit / IgG |
抗体类别 | Recombinant |
产品类型 | Antibody |
全称 | fibronectin type III domain containing 5 |
别名 | FNDC5, FRCP2 |
计算分子量 | 212 aa, 24 kDa |
观测分子量 | 25-30 kDa |
GenBank蛋白编号 | BC062297 |
基因名称 | FNDC5 |
Gene ID (NCBI) | 252995 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein A purification |
UNIPROT ID | Q8NAU1 |
储存缓冲液 | PBS only , pH 7.3 |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
fibronectin type III domain containing 5(FNDC5) encodes 23 kDa protein, which is a membrane protein that is cleaved and secreted as a newly identified hormone, irisin. Exercise-induced FNDC5 gene expression in muscles was accompanied by a parallel increase in the concentration of circulating irisin, which in turn activates adipocyte thermogenic programs, leading to mitochondrial heat production and energy expenditure.