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CoraLite® Plus 647-conjugated FOXO1 Polyclonal antibody

FOXO1 Polyclonal Antibody for
Cat No. CL647-18592

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

Forkhead box protein O1A, Forkhead box protein O1, forkhead box O1, FKHR, FKH1

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  {{ptg:cur_Conjugation}}
规格: 

-/ -


Planning an IHC experiment? We recommend our IHCeasy FOXO1 Ready-To-Use IHC Kit. FOXO1 primary antibody included.
For other applications, we recommend the unconjugated version of this antibody, 18592-1-AP

产品信息

CL647-18592 targets FOXO1 in applications and shows reactivity with human, mouse, rat samples.

经测试应用 Application Description
经测试反应性 human, mouse, rat
文献引用反应性mouse
免疫原 FOXO1 fusion protein Ag13296 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 forkhead box O1
别名 Forkhead box protein O1A, Forkhead box protein O1, forkhead box O1, FKHR, FKH1
计算分子量 655 aa, 70 kDa
观测分子量 70-80 kDa
GenBank蛋白编号BC021981
基因名称 FOXO1
Gene ID (NCBI) 2308
偶联类型 CoraLite® Plus 647 Fluorescent Dye
最大激发/发射波长654 nm / 674 nm
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ12778
储存缓冲液 PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA , pH 7.3
储存条件Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

FOXO1, also named as FOXO1A, FKHR and FKH1, is a member of the FOXO subfamily of Forkhead transcription factors. FOXO1 is a transcription factor which acts as a regulator of cell responses to oxidative stress. FOXO1 interacts with LRPPRC and SIRT1. In the presence of KIRT1, FOXO1 mediates down-regulation of cyclin D1 and up-regulation of CDKN1B levels which are required for cell transition from proliferative growth to quiescence. FOXO1 contains three predicted protein kinase B phosphorylation sites (Thr-24, Ser-256, and Ser-319) that are conserved in other FOXO proteins. The t(2;13) and the variant t(1;13) translocations generate PAX3/FKHR and PAX7/FKHR fusion proteins respectively. The resulting protein is a transcriptional activator. Defects in FOXO1 are a cause of rhabdomyosarcoma type 2 (RMS2).

发表文章

SpeciesApplicationTitle
mouse

Sci Bull (Beijing)

Purinergic signaling by TCRαβ+ double-negative T regulatory cells ameliorates liver ischemia-reperfusion injury

Authors - Hua Jin
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