验证数据展示
产品信息
18596-1-AP targets FOXP1 in ELISA applications and shows reactivity with human, mouse, rat samples.
| 经测试应用 | ELISA Application Description |
| 经测试反应性 | human, mouse, rat |
| 免疫原 | FOXP1 fusion protein Ag13402 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | forkhead box P1 |
| 别名 | 12CC4, forkhead box P1, Forkhead box protein P1, FOXP1, hFKH1B, HSPC215, QRF1 |
| 计算分子量 | 114 aa, 12 kDa |
| GenBank蛋白编号 | BC005055 |
| 基因名称 | FOXP1 |
| Gene ID (NCBI) | 27086 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q9H334 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
FOXP1, also named as HSPC215, is a transcriptional repressor that plays an important role in the specification and differentiation of lung epithelium. It is essential transcriptional regulator of B cell developmen. A chromosomal aberration involving FOXP1 is found in acute lymphoblastic leukemia. FOXP1 is implicated in the pathogenesis of DLBCL and MALT lymphomas, through the identification of recurrent chromosome translocations that upregulate its expression levels and the correlation between high-level FOXP1 expression and poor prognosis. On initial examination, these data seem contrary to findings from the study of FOXP1 in epithelial malignancies, which suggest that it may represent a tumor suppressor gene. Convincing evidence linking the loss of the FOXP1 N-terminus and malignancy has already been generated through the study of recurrent viral integration sites that generate avian nephroblastomas.(PMID:18077790) The antibody recognize 2 smaller 60-65kd isoforms in mouse Lung.