验证数据展示
经过测试的应用
Positive WB detected in | HCT 116 cells, Neuro-2a cells, mouse brain tissue, mouse lung tissue, rat brain tissue |
Positive IP detected in | mouse spleen tissue |
推荐稀释比
应用 | 推荐稀释比 |
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Western Blot (WB) | WB : 1:500-1:1000 |
Immunoprecipitation (IP) | IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate |
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Sample-dependent, Check data in validation data gallery. |
产品信息
20529-1-AP targets FOXP2 in WB, IHC, IF, IP, CoIP, ELISA applications and shows reactivity with human, mouse, rat samples.
经测试应用 | WB, IP, ELISA Application Description |
文献引用应用 | WB, IHC, IF, CoIP |
经测试反应性 | human, mouse, rat |
文献引用反应性 | human, rat |
免疫原 | FOXP2 fusion protein Ag14391 种属同源性预测 |
宿主/亚型 | Rabbit / IgG |
抗体类别 | Polyclonal |
产品类型 | Antibody |
全称 | forkhead box P2 |
别名 | CAG repeat protein 44, CAGH44, forkhead box P2, Forkhead box protein P2, FOXP2, SPCH1, TNRC10 |
计算分子量 | 80 kDa |
观测分子量 | 70-80 kDa |
GenBank蛋白编号 | BC018016 |
基因名称 | FOXP2 |
Gene ID (NCBI) | 93986 |
RRID | AB_10695756 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Antigen affinity purification |
UNIPROT ID | O15409 |
储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
FOXP2, Forkhead box protein P2, is associated with speech and language development (PMID: 24765219). FOXP2 is expressed in the brain, lungs, heart and gut. In the brain, it is widely expressed in sensory, limbic and motor structures(PMID: 10880297, PMID:15685218). Mutations in FOXP2 caused the severe speech and language disorder developmental verbal dyspraxia (PMID: 15877281). FOXP2 was detected 2 isoforms of 70 kDa and 80-82 kDa (PMID: 15056696, PMID: 29360038, PMID: 17999357).
实验方案
Product Specific Protocols | |
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WB protocol for FOXP2 antibody 20529-1-AP | Download protocol |
IP protocol for FOXP2 antibody 20529-1-AP | Download protocol |
Standard Protocols | |
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Click here to view our Standard Protocols |
发表文章
Species | Application | Title |
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Mol Ther Nucleic Acids circ-SHKBP1 Regulates the Angiogenesis of U87 Glioma-Exposed Endothelial Cells through miR-544a/FOXP1 and miR-379/FOXP2 Pathways. | ||
J Cancer Low expression of FOXP2 predicts poor survival and targets caspase-1 to inhibit cell pyroptosis in colorectal cancer.
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BMC Biol GnRH-driven FTO-mediated RNA m6A modification promotes gonadotropin synthesis and secretion | ||
Commun Biol FOXP2 overexpression upregulates LAMA4 expression and thereby alleviates preeclampsia by regulating trophoblast behavior |