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FPS-ZM1

FPS-ZM1 是一种高亲和力的 RAGE 特异性抑制剂，可阻断 Aβ 与 RAGE 的 V 结构域的结合。

CAS号

945714-67-0

分子式

C20H22ClNO

主要靶点

advanced glycation end products|Beta Amyloid

仅限科研使用

Cat No : CM02697

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Synonyms

验证数据展示

  • CAS No.: 945714-67-0

    FPS-ZM1
    CAS#: 945714-67-0

产品信息

FPS-ZM1 is a high-affinity RAGE specific inhibitor that blocks Aβ binding to the V domain of RAGE.

CAS号 945714-67-0
分子式 C20H22ClNO
主要靶点 advanced glycation end products|Beta Amyloid
主要通路 其他|神经科学
分子量 327.85
纯度 99.30%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

靶点活性

RAGE:25 nM. (Ki)

体内活性

FPS-ZM1 is nontoxic to mice and readily crossed the blood-brain barrier (BBB).It effectively controls progression of an Aβ-mediated brain disorder and the related neurovascular and cognitive dysfunction in 17-month-old APPsw/0 mice with fully developed Aβ and amyloid pathology by blocking RAGE actions at the BBB and in brain. Also, FPS-ZM1 blocks RAGE-dependent BACE1 expression and activity in brain of 17-month-old APPsw/0 mice[1].

体外活性

FPS-ZM1 blocks Aβ binding to the V domain of RAGE and inhibited Aβ40- and Aβ42-induced cellular stress in RAGE-expressing cells in vitro. It blocks binding of other ligands to RAGE as well, such as S100B, AGE, and HMGB1, which have been suggested to contribute to RAGE-mediated long-term tissue damage in models of diabetes, immune/inflammatory disorders, and AD[1].

溶解度

DMSO:198.3 mM

细胞实验

CHO cells are treated for 72 hours with different concentrations of inhibitors ranging from 10 nM to 10 μM. The cellular toxicity was determined using the WST-8 Assay Kit. (Only for Reference)

参考文献

1.Deane R, et al. J Clin Invest. 2012, 122(4):1377-1392.
2.He C, Sun S, Zhang Y, et al. The role of irreversible electroporation in promoting M1 macrophage polarization via regulating the HMGB1-RAGE-MAPK axis in pancreatic cancer[J]. OncoImmunology. 2021, 10(1): 1897295.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2