验证数据展示
发表文章中的应用
| WB | See 1 publications below |
| IHC | See 4 publications below |
产品信息
10474-1-AP targets Follistatin in WB, IHC, ELISA applications and shows reactivity with human samples.
| 经测试应用 | ELISA Application Description |
| 文献引用应用 | WB, IHC |
| 经测试反应性 | human |
| 文献引用反应性 | human, mouse, rat |
| 免疫原 | Follistatin fusion protein Ag0775 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | follistatin |
| 别名 | Activin binding protein, follistatin, FS, FST |
| 计算分子量 | 33 aa, 7 kDa |
| GenBank蛋白编号 | BC004107 |
| 基因名称 | Follistatin |
| Gene ID (NCBI) | 10468 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | P19883 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
Follistatin (FST) is a member of the tissue growth factor β family and is a secreted glycoprotein that antagonizes many members of the family, including activin A, growth differentiation factor11 , and myostatin. It binds activin A with high affinity and whose expression can be induced by activin A and several other pro-inflammatory cytokines. Activin A-follistatin complexes are biologically inactive and bind to cell surface heparan sulphate-containing proteoglycans for internalisation and degradation. It has also been found to play a significant role in the management of skeletal muscle size and mass. It also has important roles in early embryonic development, differentiation of ovarian granulosa cells, liver fibrosis and polycystic ovarian syndrome.
发表文章
| Species | Application | Title |
|---|---|---|
Am J Pathol Initial Suppression of Transforming Growth Factor-β Signaling and Loss of TGFBI Causes Early Alveolar Structural Defects Resulting in Bronchopulmonary Dysplasia. | ||
Mol Pharm Development of a nitric oxide-releasing analogue of the muscle relaxant guaifenesin for skeletal muscle satellite cell myogenesis. | ||
Cell Commun Signal Activin A induces growth arrest through a SMAD- dependent pathway in hepatic progenitor cells. | ||
J Int Med Res Expression of activin A and follistatin in glioblastoma and their effects on U87 in vitro. |