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Anti-Human Fas/CD95 Rabbit Recombinant Antibody, PBS Only

Fas/CD95 Uni-rAbTM Recombinant Antibody for FC

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Conjugate

Unconjugated

CloneNo.

240340E11

Cat no : 98034-1-PBS

Print datasheet

Synonyms

FAS, APT1, Apoptosis-mediating surface antigen FAS, Apo-1 antigen, APO-1

验证数据展示

  • FC experiment of human PBMCs using 98034-1-RR (same clone as 98034-1-PBS)

    FC experiment of human PBMCs using 98034-1-RR (same clone as 98034-1-PBS)

    1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human Fas/CD95 Rabbit Recombinant Antibody (98034-1-RR, Clone: 240340E11) or 0.25 ug Isotype Control, and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with APC Anti-Human CD45RO (UCHL1) (APC-65150, Clone: UCHL1). Cells were not fixed. This data was developed using the same antibody clone with 98034-1-PBS in a different storage buffer formulation.

  • FC experiment of human PBMCs using 98034-1-RR (same clone as 98034-1-PBS)

    FC experiment of human PBMCs using 98034-1-RR (same clone as 98034-1-PBS)

    1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human Fas/CD95 Rabbit Recombinant Antibody (98034-1-RR, Clone: 240340E11) (red), or 0.25 ug Isotype Control (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98034-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98034-1-RR

    Affinity and Kinetic Characterization of 98034-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98034-1-RR against Human Fas/CD95 were performed. The affinity constant is 1.97 nM.

产品信息

The immunogen of 98034-1-PBS is Fas/CD95 Fusion Protein expressed in E. coli.

Tested Applications FC Application Description
Tested Reactivity human
Immunogen Fusion Protein 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name Fas (TNF receptor superfamily, member 6)
Synonyms FAS, APT1, Apoptosis-mediating surface antigen FAS, Apo-1 antigen, APO-1
Calculated Molecular Weight38 kDa
GenBank Accession NumberNM_000043.6
Gene Symbol Fas/CD95
Gene ID (NCBI) 355
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDP25445-1
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

FAS, also named as CD95, APO-1, APT1, FAS1 and TNFRSF6, is a receptor for TNFSF6/FASLG. It is a cell surface receptor belonging to the TNF receptor superfamily, can mediate apoptosis by ligation with an agonistic anti-Fas antibody or Fas ligand. Stimulation of Fas results in the aggregation of its intracellular death domains, leading to the formation of the death-inducing signaling complex (DISC). FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both.