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Fasentin

Fasentin (N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide) 是葡萄糖摄取抑制剂，可抑制GLUT-1/GLUT-4转运蛋白，优先抑制 GLUT4，IC50为 68 μM。它是死亡受体刺激敏化剂，可敏化细胞对 FAS 诱导的细胞死亡，具有抗血管生成活性。

CAS号

392721-37-8

分子式

C11H9ClF3NO2

主要靶点

transporter

仅限科研使用

Cat No : CM04264

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Synonyms

N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide

验证数据展示

  • CAS No.: 392721-37-8

    Fasentin
    CAS#: 392721-37-8

产品信息

Fasentin is an inhibitor of GluT1.

CAS号 392721-37-8
分子式 C11H9ClF3NO2
主要靶点 transporter
主要通路 代谢
分子量 279.64
纯度 99.95%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide

靶点活性

GLUT4:68 μM (IC50)

体外活性

Fasentin has been described as a modulator of GLUT-1 and GLUT-4 transporters, thus inhibiting glucose uptake in some cancer cells.

溶解度

DMSO:25 mg/mL (89.4 mM)

参考文献

1.Ocaa M C , Beatriz Martínez-Poveda, Manuel Marí-Beffa, et al. Fasentin diminishes endothelial cell proliferation, differentiation and invasion in a glucose metabolism-independent manner[J]. entific Reports, 2020, 10(1). 2.Kraus, Dominik, Reckenbeil, et al. Targeting glucose transport and the NAD pathway in tumor cells with STF-31: a re-evaluation[J]. Cellular Oncology, 2018.

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