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Fetuin-A/AHSG Recombinant antibody, PBS Only

Fetuin-A/AHSG Uni-rAbTM Recombinant Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

1E4

Cat no : 80793-1-PBS

Print datasheet

Synonyms

AHSG, Fetuin-A, Alpha 2 Z globulin, alpha 2 HS glycoprotein, AHS

验证数据展示

  • WB analysis of human plasma using 80793-1-RR (same clone as 80793-1-PBS)

    WB analysis of human plasma using 80793-1-RR (same clone as 80793-1-PBS)

    human plasma were subjected to SDS PAGE followed by western blot with 80793-1-RR (Fetuin-A antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 80793-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 80793-1-RR

    Affinity and Kinetic Characterization of 80793-1-RR

    Biolayer interferometry (BLl) kinetic assays of 80793-1-RR against Human AHSG were performed. The affinity constant is 5.52 nM.

Planning an IHC experiment? We recommend our IHCeasy AHSG/Fetuin A Ready-To-Use IHC Kit. AHSG/Fetuin A primary antibody included.

产品信息

80793-1-PBS targets Fetuin-A/AHSG in WB, Indirect ELISA applications and shows reactivity with human samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity human
Immunogen Fetuin-A/AHSG fusion protein Ag9853 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name alpha-2-HS-glycoprotein
Synonyms AHSG, Fetuin-A, Alpha 2 Z globulin, alpha 2 HS glycoprotein, AHS
Calculated Molecular Weight 367 aa, 39 kDa
Observed Molecular Weight58 kDa
GenBank Accession NumberBC048198
Gene Symbol Fetuin-A
Gene ID (NCBI) 197
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP02765
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Fetuin-A, also named as Alpha2-HS glycoprotein (AHSG), is a member of cystatin superfamily of protease inhibitors. It is a highly expressed glycoprotein in various fetal tissues whereas it is mainly expressed by the liver in adults. Fetuin A, an extracellular inhibitor of transforming growth factor β, is a profibrogenic stimulus in liver disease. Circulating fetuin-A may be a beneficial serum biomarker in the detection of liver and vascular fibrosis progression in patients with non-alcoholic fatty liver disease. It is also involved in several functions, such as endocytosis, brain development and the formation of bone tissue. Fetuin-A exerts its effects on the cardiovascular system by two different mechanisms. On the one hand it inhibits ins signaling and induces ins resistance contributing to the onset of atherosclerosis and on the other hand it inhibits calcium deposition and protects from vascular calcification.