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Fibrinogen Beta Chain Monoclonal antibody, PBS Only

Fibrinogen Beta Chain Monoclonal Antibody for WB,Indirect ELISA

Host / Isotype

Mouse / IgG2b

Reactivity

human

Applications

WB,Indirect ELISA

Conjugate

Unconjugated

CloneNo.

1F8E4

Cat No : 66186-1-PBS

Print datasheet

Synonyms

FGB, fibrinogen beta chain

验证数据展示

  • WB analysis of human heart using 66186-1-Ig (same clone as 66186-1-PBS)

    WB analysis of human heart using 66186-1-Ig (same clone as 66186-1-PBS)

    human heart tissue were subjected to SDS PAGE followed by western blot with 66186-1-Ig (Fibrinogen beta chain antibody at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66186-1-PBS in a different storage buffer formulation.

Planning an IHC experiment? We recommend our IHCeasy FGB Ready-To-Use IHC Kit. FGB primary antibody included.

产品信息

66186-1-PBS targets Fibrinogen Beta Chain in WB, Indirect ELISA applications and shows reactivity with human samples.

Tested Applications WB,Indirect ELISA Application Description
Tested Reactivity human
Immunogen Fibrinogen Beta Chain fusion protein Ag10205 种属同源性预测
Host / Isotype Mouse / IgG2b
Class Monoclonal
Type Antibody
Full Name fibrinogen beta chain
Synonyms FGB, fibrinogen beta chain
Calculated Molecular Weight 491 aa, 56 kDa
Observed Molecular Weight 50 kDa
GenBank Accession NumberBC107766
Gene Symbol FGB
Gene ID (NCBI) 2244
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP02675
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

背景介绍

Fibrinogen is a soluble plasma glycoprotein synthesized in the liver. It is composed of two sets of three structurally different subunits: alpha (FGA), beta (FGB), gamma (FGG). Fibrinogen is converted by thrombin into fibrin during blood coagulation. Fibrinogen and fibrin play overlapping roles in blood clotting, fibrinolysis, cellular and matrix interactions, the inflammatory response, wound healing, and neoplasia (PMID: 16102057). FGB is the beta chain of fibrinogen. During conversion of fibrinogen to fibrin, fibrinopeptide B is cleaved from FGB by thrombin. Mutations in the gene of FGB lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency.