验证数据展示
产品信息
29272-1-PBS targets GAB2 in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.
Tested Applications | WB, IHC, Indirect ELISA Application Description |
Tested Reactivity | human |
Immunogen | GAB2 fusion protein Ag30347 种属同源性预测 |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Full Name | GRB2-associated binding protein 2 |
Synonyms | |
Calculated Molecular Weight | 676 aa, 74 kDa |
Observed Molecular Weight | 74-90 kDa |
GenBank Accession Number | BC131711 |
Gene Symbol | GAB2 |
Gene ID (NCBI) | 9846 |
RRID | AB_2918265 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen affinity purification |
UNIPROT ID | Q9UQC2 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Growth factor receptor-bound protein 2 (GAB2), an adaptor protein, belongs to the Gab family and is involved in various biologic processes. Gab2 mainly mediates phosphatidylinositol 3-kinase (PI3K) and extracellular signal-regulated kinase (ERK) signaling pathways. Furthermore, Gab2 governs tumorigenic signaling and is a novel potential therapeutic target in leukemia, breast cancer, ovarian cancer, and melanoma. Gab2 is the major 98-kDa phosphoprotein associated with SHP-2, PI 3-kinase, and Grb2 in normal human lymphocytes. (PMID: 32269703, PMID: 28842424, PMID: 28420432, PMID: 10849428)