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GABRA6 Polyclonal antibody

GABRA6 Polyclonal Antibody for IHC, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

IHC, ELISA

Conjugate

Unconjugated

Cat no : 21766-1-AP

Print datasheet

Synonyms

GABA A receptor alpha 6, GABAA receptor alpha 6, GABRA6

验证数据展示

  • IHC staining of mouse cerebellum using 21766-1-AP

    IHC staining of mouse cerebellum using 21766-1-AP

    Immunohistochemical analysis of paraffin-embedded mouse cerebellum tissue slide using 21766-1-AP (GABRA6 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  • IHC staining of mouse cerebellum using 21766-1-AP

    IHC staining of mouse cerebellum using 21766-1-AP

    Immunohistochemical analysis of paraffin-embedded mouse cerebellum tissue slide using 21766-1-AP (GABRA6 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

经过测试的应用

Positive IHC detected inmouse cerebellum tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

推荐稀释比

ApplicationDilution
Immunohistochemistry (IHC)IHC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

21766-1-AP targets GABRA6 in IHC, ELISA applications and shows reactivity with human, mouse samples.

Tested Applications IHC, ELISA Application Description
Tested Reactivity human, mouse
Immunogen GABRA6 fusion protein Ag16375 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name gamma-aminobutyric acid (GABA) A receptor, alpha 6
Synonyms GABA A receptor alpha 6, GABAA receptor alpha 6, GABRA6
Calculated Molecular Weight 453 aa, 51 kDa
GenBank Accession NumberBC096241
Gene Symbol GABRA6
Gene ID (NCBI) 2559
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ16445
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABAA receptors, which are ligand-gated chloride channels. GABAA receptors are formed by pentameric assembly of 19 different subunit subtypes (α1-α6, β1-β3, γ1-γ3, δ, ɛ, π, θ and ρ1-ρ3) (PMID: 21930603). The mutation R46W of GABRA6 is associated with the pathogenesis of childhood absence epilepsy (CAE) (PMID: 21930603).

实验方案

Product Specific Protocols
IHC protocol for GABRA6 antibody 21766-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols