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验证数据展示

  • WB analysis using 11854-1-AP (same clone as 11854-1-PBS)

    WB analysis using 11854-1-AP (same clone as 11854-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 11854-1-AP (GBP2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11854-1-PBS in a different storage buffer formulation.

  • IHC staining of human spleen using 11854-1-AP (same clone as 11854-1-PBS)

    IHC staining of human spleen using 11854-1-AP (same clone as 11854-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human spleen tissue slide using 11854-1-AP (GBP2 antibody) at dilution of 1:200 (under 10x lens). This data was developed using the same antibody clone with 11854-1-PBS in a different storage buffer formulation.

  • IHC staining of human spleen using 11854-1-AP (same clone as 11854-1-PBS)

    IHC staining of human spleen using 11854-1-AP (same clone as 11854-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human spleen tissue slide using 11854-1-AP (GBP2 antibody) at dilution of 1:200 (under 40x lens). This data was developed using the same antibody clone with 11854-1-PBS in a different storage buffer formulation.

  • IF Staining of HeLa using 11854-1-AP (same clone as 11854-1-PBS)

    IF Staining of HeLa using 11854-1-AP (same clone as 11854-1-PBS)

    Immunofluorescent analysis of (-20°C Ethanol) fixed HeLa cells using GBP2 antibody (11854-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 11854-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO验证

GBP2 Polyclonal antibody, PBS Only

GBP2 Polyclonal Antibody for WB, IHC, IF/ICC, Indirect ELISA
Cat No. 11854-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, IF/ICC, Indirect ELISA

别名

EC:3.6.5.-, GBP 2, GBP-2, GTP-binding protein 2, Guanine nucleotide-binding protein 2

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

11854-1-PBS targets GBP2 in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, IF/ICC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原 GBP2 fusion protein Ag2425 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 guanylate binding protein 2, interferon-inducible
别名 EC:3.6.5.-, GBP 2, GBP-2, GTP-binding protein 2, Guanine nucleotide-binding protein 2
计算分子量 591 aa, 67 kDa
观测分子量 67 kDa
GenBank蛋白编号BC022272
基因名称 GBP2
Gene ID (NCBI) 2634
RRIDAB_2109336
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDP32456
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

GBP2 is a member of the GTPase family and is crucial to host immunity against pathogens. GBP2 is also used as a marker of interferon (IFN) responsiveness because it is one of the most highly expressed genes after IFN-γ stimulation. Increased GBP2 expression is also associated with a better prognosis in breast cancer and may have a role in T-cell defense against breast cancer. Interestingly, GBP2 expression in NIH/3T3 fibroblasts inhibited Rac activation and matrix metalloproteinase-9 expression, suggesting a possible role for GBP2 in regulating cancer metastasis. The molecular weight of GBP2 is 67 kDa. (PMID: 29072687, 35383115)