验证数据展示
产品信息
82847-1-PBS targets GNRHR in WB, Indirect ELISA applications and shows reactivity with Human, mouse samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | Human, mouse |
| 免疫原 | Peptide 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | GnRH receptor |
| 别名 | GnRH R, GnRH receptor, GNRHR, GNRHR1, GRHR, LHRHR, LRHR |
| 计算分子量 | 38 kDa |
| 观测分子量 | ~38 kDa |
| GenBank蛋白编号 | NM_000406 |
| 基因名称 | GNRHR |
| Gene ID (NCBI) | 2798 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | P30968 |
| 储存缓冲液 | PBS only , pH 7.3 |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
GNRHR, also named GRHR, belongs to the G-protein coupled receptor 1 family. GNRHR is a receptor for GnRH that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). It mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform2 of GNRHR may act as an inhibitor of GnRH-R signaling. Defects in GNRHR are a cause of idiopathic hypogonadotropic hypogonadism (IHH). Defects in GNRHR are a cause of fertile eunuch syndrome. The predicted unmodified molecular weight of the human GNRHR is ~38 kDa, the larger band (50-65 kDa) is likely to represent a glycosylated form of GNRHR.