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GPNMB Polyclonal antibody
GPNMB Polyclonal Antibody for ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human, mouse and More (1)
Applications
ELISA and More (3)
Conjugate
Unconjugated
验证数据展示
产品信息
The immunogen of 20338-1-AP is GPNMB Fusion Protein expressed in E. coli.
| Tested Applications | ELISA Application Description |
| Cited Applications | WB, IF, IHC |
| Tested Reactivity | human, mouse |
| Cited Reactivity | human, mouse, rat |
| Immunogen | GPNMB fusion protein Ag14124 种属同源性预测 |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Full Name | glycoprotein (transmembrane) nmb |
| Synonyms | GPNMB, HGFIN, Transmembrane glycoprotein NMB |
| Calculated Molecular Weight | 64 kDa |
| Observed Molecular Weight | 68 kDa |
| GenBank Accession Number | BC011595 |
| Gene Symbol | GPNMB |
| Gene ID (NCBI) | 10457 |
| RRID | AB_10667459 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q14956 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
GPNMB also known as HGFIN, osteoactivin, and DC-HIL, is a type I membrane glycoprotein involved in various biological processes, including inflammation, invasion and metastasis of malignant tumors, cell differentiation, and tissue regeneration. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB acts as an osteogenic factor that stimulates osteoblast differentiation in vivo and in vitro.
发表文章
| Species | Application | Title |
|---|---|---|
J Cell Physiol Transcriptome analysis reveals GPNMB as a potential therapeutic target for gastric cancer. | ||
BMC Med Genomics Genomic profiling of rectal adenoma and carcinoma by array-based comparative genomic hybridization. | ||
Inflammation Glycoprotein Nonmetastatic Melanoma Protein B (GPNMB) Ameliorates the Inflammatory Response in Periodontal Disease. | ||
Pathol Oncol Res GPNMB-Positive Cells in Head and Neck Squamous Cell Carcinoma-Their Roles in Cancer Stemness, Therapy Resistance, and Metastasis | ||
J Biomater Appl The anti-inflammatory and osteogenic activity of chitosan/polyvinyl alcohol/graphene oxide/astaxanthin nanofibers membranes in vitro study. |