验证数据展示
经过测试的应用
| Positive WB detected in | HEK-293 cells, mouse cerebellum tissue |
| Positive IF/ICC detected in | HEK-293 cells |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Western Blot (WB) | WB : 1:500-1:1000 |
| Immunofluorescence (IF)/ICC | IF/ICC : 1:10-1:100 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
25076-1-AP targets GPR107 in WB, IHC, IF/ICC, ELISA applications and shows reactivity with human, mouse samples.
| 经测试应用 | WB, IF/ICC, ELISA Application Description |
| 文献引用应用 | WB, IHC, IF |
| 经测试反应性 | human, mouse |
| 文献引用反应性 | human, mouse |
| 免疫原 | GPR107 fusion protein Ag18649 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | G protein-coupled receptor 107 |
| 别名 | G protein coupled receptor 107, GCDRP, GPR107, KIAA1624, LUSTR1, Protein GPR107, RP11 88G17 |
| 计算分子量 | 552 aa, 67 kDa |
| 观测分子量 | 60-67 kDa |
| GenBank蛋白编号 | BC110518 |
| 基因名称 | GPR107 |
| Gene ID (NCBI) | 57720 |
| RRID | AB_2879886 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q5VW38 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
GPR107 also named as KIAA1624 or LUSTR1 is 600 amino acid protein, which belongs to the LU7TM family. GPR107 localizes in membrane and is a multi-pass membrane protein. GPR107 is a promising candidate receptor for neuronostatin, and neuronostatin, interacting with GPR107, may play an important role in the central control of cardiovascular function.
实验方案
| Product Specific Protocols | |
|---|---|
| WB protocol for GPR107 antibody 25076-1-AP | Download protocol |
| IF protocol for GPR107 antibody 25076-1-AP | Download protocol |
| FC protocol for GPR107 antibody 25076-1-AP | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
发表文章
| Species | Application | Title |
|---|---|---|
Nat Chem Biol A proteome-wide map of 20(S)-hydroxycholesterol interactors in cell membranes. | ||
J Exp Clin Cancer Res LncGPR107 drives the self-renewal of liver tumor initiating cells and liver tumorigenesis through GPR107-dependent manner. | ||
Neurochem Res Neuronostatin Promotion Soluble Aβ1-42 Oligomers: Induced Dysfunctional Brain Glucose Metabolism in Mice. | ||
Behav Brain Res Neuronostatin promotes soluble Aβ1-42 oligomers -induced spatial learning and memory impairments in mice.
| ||
Nat Chem Biol Chemoproteomics reveals microbiota-derived aromatic monoamine agonists for GPRC5A | ||
Neuropharmacology Neuronostatin regulates neuronal function and energetic metabolism in Alzheimer's disease in a GPR107-dependent manner
|
