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  • Featured Product
  • KD/KO Validated

GPR126 Polyclonal antibody

GPR126 Polyclonal Antibody for IHC, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

IHC, ELISA and More (1)

Conjugate

Unconjugated

Cat no : 17774-1-AP

Print datasheet

Synonyms

ADGRG6, APG1, DREG, G protein coupled receptor 126, GPR126, PS1TP2, VIGR

验证数据展示

  • IHC staining of mouse kidney using 17774-1-AP

    IHC staining of mouse kidney using 17774-1-AP

    Immunohistochemical analysis of paraffin-embedded mouse kidney tissue slide using 17774-1-AP (GPR126 antibody) at dilution of 1:200 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  • IHC staining of mouse kidney using 17774-1-AP

    IHC staining of mouse kidney using 17774-1-AP

    Immunohistochemical analysis of paraffin-embedded mouse kidney tissue slide using 17774-1-AP (GPR126 antibody) at dilution of 1:200 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  • IHC staining of mouse kidney using 17774-1-AP

    IHC staining of mouse kidney using 17774-1-AP

    Immunohistochemical analysis of paraffin-embedded mouse kidney tissue slide using 17774-1-AP (GPR126 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  • IHC staining of mouse kidney using 17774-1-AP

    IHC staining of mouse kidney using 17774-1-AP

    Immunohistochemical analysis of paraffin-embedded mouse kidney tissue slide using 17774-1-AP (GPR126 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

经过测试的应用

Positive IHC detected inmouse kidney tissue, mouse lung tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

推荐稀释比

ApplicationDilution
Immunohistochemistry (IHC)IHC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

The immunogen of 17774-1-AP is GPR126 Fusion Protein expressed in E. coli.

Tested Applications IHC, ELISA Application Description
Cited ApplicationsWB, IHC
Tested Reactivity human, mouse, rat
Cited Reactivityhuman
Immunogen GPR126 fusion protein Ag12195 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name G protein-coupled receptor 126
Synonyms ADGRG6, APG1, DREG, G protein coupled receptor 126, GPR126, PS1TP2, VIGR
Calculated Molecular Weight 1222 aa, 137 kDa
GenBank Accession NumberBC075798
Gene Symbol GPR126
Gene ID (NCBI) 57211
RRIDAB_2878439
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ86SQ4
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

GPR126 (G protein-coupled receptor 126) is a member of the adhesion GPCR family. GPR126 is all widely expressed on stromal cells (PMID: 25713288). It is essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons (PMID: 24227709). GPR126 regulates neural, cardiac and ear development by G-protein- and/or N-terminus-dependent signaling (PMID: 24082093, PMID: 24067352). GPR126 also stimulates VEGF signaling and angiogenesis by modulating VEGF receptor 2 expression through STAT5 and GATA2 in endothelial cells.

实验方案

Product Specific Protocols
IHC protocol for GPR126 antibody 17774-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

发表文章

SpeciesApplicationTitle
humanWB,IHC

Proc Natl Acad Sci U S A

Progesterone activates GPR126 to promote breast cancer development via the Gi pathway.

Authors - Wentao An
  • KD Validated
View Article