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GPR17 Polyclonal antibody

GPR17 Polyclonal Antibody for IF-P, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

IF-P, ELISA

Conjugate

Unconjugated

Cat no : 13416-1-AP

Print datasheet

Synonyms

UDP/CysLT receptor, R12, P2Y-like receptor, P2Y like receptor, G-protein coupled receptor 17

验证数据展示

  • IF Staining of mouse cerebellum using 13416-1-AP

    IF Staining of mouse cerebellum using 13416-1-AP

    Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded mouse cerebellum tissue using GPR17 antibody (13416-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

经过测试的应用

Positive IF-P detected inmouse cerebellum tissue

推荐稀释比

ApplicationDilution
Immunofluorescence (IF)-PIF-P : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

13416-1-AP targets GPR17 in IF-P, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Applications IF-P, ELISA Application Description
Tested Reactivity human, mouse, rat
Immunogen GPR17 fusion protein Ag4106 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name G protein-coupled receptor 17
Synonyms UDP/CysLT receptor, R12, P2Y-like receptor, P2Y like receptor, G-protein coupled receptor 17
Calculated Molecular Weight 367 aa, 41 kDa
Observed Molecular Weight 50 kDa
GenBank Accession NumberBC031653
Gene Symbol GPR17
Gene ID (NCBI) 2840
RRIDAB_2279341
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ13304
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

GPR17 is a G protein-coupled receptor (GPCR) that plays a significant role in various physiological processes, particularly in the central nervous system (CNS). GPR17 is considered a modulator of CNS myelination and is involved in reconstructing and repairing demyelinating plaques caused by ongoing inflammatory processes, such as in multiple sclerosis (MS). It is present in nerve cells and precursor oligodendrocyte cells, playing a role in the differentiation and maturation of oligodendrocytes (PMID: 32182666). GPR17 is a multifaceted GPCR with implications in immune regulation, glucose metabolism, neurodegenerative diseases, and potentially in treating anxiety disorders.

实验方案

Product Specific Protocols
IF protocol for GPR17 antibody 13416-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols