验证数据展示
产品信息
14820-1-PBS targets GPR37/Pael-R in WB, IHC, IF/ICC, IF-P, Indirect ELISA applications and shows reactivity with human, mouse samples.
Tested Applications | WB, IHC, IF/ICC, IF-P, Indirect ELISA Application Description |
Tested Reactivity | human, mouse |
Immunogen | GPR37/Pael-R fusion protein Ag6591 种属同源性预测 |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Full Name | G protein-coupled receptor 37 (endothelin receptor type B-like) |
Synonyms | GPR37, Pael-R, G-protein coupled receptor 37, ETBR-LP-1, ETBR LP 1 |
Calculated Molecular Weight | 67 kDa |
Observed Molecular Weight | 50-55 kDa |
GenBank Accession Number | BC040007 |
Gene Symbol | GPR37 |
Gene ID (NCBI) | 2861 |
RRID | AB_2232549 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen affinity purification |
UNIPROT ID | O15354 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
The orphan G protein-coupled receptor GPR37, also known as PAELR (parkin-associated endothelin receptor-like receptor) or ETBR-LP-1 (endothelin B receptor-like protein 1), is a 613 aa, multi-pass membrane protein predominantly expressed in the brain. It is a substrate of parkin (PARK2). When overexpressed in cells, GPR37 tends to become insoluble, unfolded, and ubiquitinated in vivo. Accumulation of the unfolded protein may lead to dopaminergic neuronal death in juvenile Parkinson disease (JPD). This antibody recognizes endogenous GPR37, which migrates as an approximately 50-55 kDa band in SDS-PAGE (PMID:17519329).