• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

验证数据展示

  • IF Staining of HeLa using 14820-1-AP (same clone as 14820-1-PBS)

    IF Staining of HeLa using 14820-1-AP (same clone as 14820-1-PBS)

    Immunofluorescent analysis of (-20°C Methanol) fixed HeLa cells using GPR37/Pael-R antibody (14820-1-AP) at dilution of 1:100 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 14820-1-PBS in a different storage buffer formulation.

  • WB analysis of mouse brain using 14820-1-AP (same clone as 14820-1-PBS)

    WB analysis of mouse brain using 14820-1-AP (same clone as 14820-1-PBS)

    mouse brain tissue were subjected to SDS PAGE followed by western blot with 14820-1-AP (GPR37/Pael-R antibody) at dilution of 1:1600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14820-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse brain using 14820-1-AP (same clone as 14820-1-PBS)

    IHC staining of mouse brain using 14820-1-AP (same clone as 14820-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 14820-1-AP (GPR37/Pael-R antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 14820-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse brain using 14820-1-AP (same clone as 14820-1-PBS)

    IHC staining of mouse brain using 14820-1-AP (same clone as 14820-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 14820-1-AP (GPR37/Pael-R antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 14820-1-PBS in a different storage buffer formulation.

  • IF Staining of mouse brain using 14820-1-AP (same clone as 14820-1-PBS)

    IF Staining of mouse brain using 14820-1-AP (same clone as 14820-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed mouse brain tissue using GPR37/Pael-R antibody (14820-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 14820-1-PBS in a different storage buffer formulation.

  • IF Staining of mouse brain using 14820-1-AP (same clone as 14820-1-PBS)

    IF Staining of mouse brain using 14820-1-AP (same clone as 14820-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed mouse brain tissue using GPR37/Pael-R antibody (14820-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 14820-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO验证

GPR37/Pael-R Polyclonal antibody, PBS Only

GPR37/Pael-R Polyclonal Antibody for WB, IHC, IF/ICC, IF-P, Indirect ELISA
Cat No. 14820-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

WB, IHC, IF/ICC, IF-P, Indirect ELISA

别名

GPR37, Pael-R, G-protein coupled receptor 37, ETBR-LP-1, ETBR LP 1

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

点击咨询售前客服

点击咨询售后客服

产品信息

14820-1-PBS targets GPR37/Pael-R in WB, IHC, IF/ICC, IF-P, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, IHC, IF/ICC, IF-P, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原 GPR37/Pael-R fusion protein Ag6591 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 G protein-coupled receptor 37 (endothelin receptor type B-like)
别名 GPR37, Pael-R, G-protein coupled receptor 37, ETBR-LP-1, ETBR LP 1
计算分子量 67 kDa
观测分子量 50-55 kDa
GenBank蛋白编号BC040007
基因名称 GPR37
Gene ID (NCBI) 2861
RRIDAB_2232549
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDO15354
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

The orphan G protein-coupled receptor GPR37, also known as PAELR (parkin-associated endothelin receptor-like receptor) or ETBR-LP-1 (endothelin B receptor-like protein 1), is a 613 aa, multi-pass membrane protein predominantly expressed in the brain. It is a substrate of parkin (PARK2). When overexpressed in cells, GPR37 tends to become insoluble, unfolded, and ubiquitinated in vivo. Accumulation of the unfolded protein may lead to dopaminergic neuronal death in juvenile Parkinson disease (JPD). This antibody recognizes endogenous GPR37, which migrates as an approximately 50-55 kDa band in SDS-PAGE (PMID:17519329).