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GPR84 Antagonist 8

GPR84 antagonist 8 is a selective GPR84 antagonist.

CAS号

1445846-30-9

分子式

C23H23N3O5

主要靶点

GPCR

仅限科研使用

Cat No : CM04294

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Synonyms

验证数据展示

  • CAS No.: 1445846-30-9

    GPR84 Antagonist 8
    CAS#: 1445846-30-9

  • GPR84 Antagonist 8<br/>CAS#: 1445846-30-9

    GPR84 Antagonist 8
    CAS#: 1445846-30-9

产品信息

GPR84 is a medium chain fatty acid (MCFA) receptor, with capric acid (a 10-carbon chain fatty acid) being the most potent ligand. It is highly expressed in the cells of myeloid lineage that constitute the innate immune system, including monocytes, macrophages, and neutrophils in the periphery and microglia in the brain. GPR84 Antagonist 8 is a selective GPR84 antagonist from the patent literature (Galapagos NV Company, US 2013/0165437 A1). As a GPCR antagonist, GPR84 Antagonist 8 dose-dependently inhibited the action of 6-OAU in decreasing cAMP production in GPR84-CHO cells. Blockade of GPR84 activation by pre-treatment with GPR84 Antagonist 8 at 10μM for 30min before adding 1μM GPR84 agonist 6-OAU in LPS pre-treated BMDMs, reduced the expression of TNFα, IL-6, IL12b, CCL2, CCL5, and CXCL1, as well as partially blocked the phosphorylation of AKT and ERK induced by 6-OAU. GPR84 Antagonist 8 at 10μM could antagonize the migration, bacterial adhesion, and phagocytosis promoted by 6-OAU mediated—GPR84 activation in macrophages. Pretreatment with GPR84 Antagonist 8 at 10μM for 1h blocked 6-OAU induced U937 cell migration.

CAS号 1445846-30-9
分子式 C23H23N3O5
主要靶点 GPCR
主要通路 GPCR/G Protein
分子量 421.4458
MDL NO
Pubchem ID 71598639.0
纯度 97%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件
粉末 -20°C 3年
液体 -80°C 1年
运输条件 Shipped in cold pack
别名

靶点

TargetActivity

溶解度

DMSO5 mg/mL

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
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×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2