验证数据展示
经过测试的应用
Positive IHC detected in | mouse bladder tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
推荐稀释比
应用 | 推荐稀释比 |
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Immunohistochemistry (IHC) | IHC : 1:50-1:500 |
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Sample-dependent, Check data in validation data gallery. |
产品信息
25999-1-AP targets GPR87 in IHC, ELISA applications and shows reactivity with human, mouse samples.
经测试应用 | IHC, ELISA Application Description |
经测试反应性 | human, mouse |
免疫原 | GPR87 fusion protein Ag23214 种属同源性预测 |
宿主/亚型 | Rabbit / IgG |
抗体类别 | Polyclonal |
产品类型 | Antibody |
全称 | G protein-coupled receptor 87 |
别名 | FKSG78, G protein coupled receptor 87, G protein coupled receptor 95, GPR87, GPR95, KPG_002 |
GenBank蛋白编号 | BC132888 |
基因名称 | GPR87 |
Gene ID (NCBI) | 53836 |
RRID | AB_3085833 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Antigen affinity purification |
UNIPROT ID | Q9BY21 |
储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
G Protein-Coupled Receptor 87 (GPR87) is a GPCR, and it has been demonstrated to regulate the progression of several tumors (PMID:18183596). Studied reported that GPR87 promotes PDA (Pancreatic ductal adenocarcinoma) proliferation, angiogenesis, gemcitabine resistance, and tumorigenicity through activating the nuclear factor-kB (NF-kB) pathway (PMID:32405536). GPR87 is an independent prognostic factor for bladder cancer intravesical recurrence; it promotes bladder cancer cell proliferation and inhibits apoptosis. In addition, GPR87 was deorphanized and shown to be a lysophosphatidic acid (LPA) receptor (PMID:23752273).
实验方案
Product Specific Protocols | |
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IHC protocol for GPR87 antibody 25999-1-AP | Download protocol |
Standard Protocols | |
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Click here to view our Standard Protocols |