验证数据展示
产品信息
11608-2-AP targets GPSM2 in WB, IHC, IF, IP, ELISA applications and shows reactivity with human samples.
| 经测试应用 | ELISA Application Description |
| 文献引用应用 | WB, IHC, IF, IP |
| 经测试反应性 | human |
| 文献引用反应性 | human, mouse |
| 免疫原 | GPSM2 fusion protein Ag2167 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | G-protein signaling modulator 2 (AGS3-like, C. elegans) |
| 别名 | GPSM2, LGN, Mosaic protein LGN, Pins |
| 计算分子量 | 75 kDa |
| GenBank蛋白编号 | BC027732 |
| 基因名称 | GPSM2 |
| Gene ID (NCBI) | 29899 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | P81274 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
GPSM2 belongs to a family of proteins that modulate activation of G proteins. GPSM2 assists in the exchange of guanine nucleotides, and allows extracellular signals to be transmitted to cells via cell surface, and ultimately plays a key role in the activation of G-proteins. Therefore, GPSM2 is a critical factor for the stability of cell division. Some recent studies have shown that GPSM2 messenger RNA (mRNA) is overexpressed and plays a positive role in the development of certain tumors, such as liver cancer, pancreatic cancer, breast cancer. It also plays a role in neuroblast division and in the development of normal hearing. Mutations in GPSM2 are associated with autosomal recessive nonsyndromic deafness (DFNB82), which is a form of non-syndromic deafness characterized by prelingual, bilateral, severe, sensorineural hearing loss.
发表文章
| Species | Application | Title |
|---|---|---|
Am J Hum Genet Whole exome sequencing and homozygosity mapping identify mutation in the cell polarity protein GPSM2 as the cause of nonsyndromic hearing loss DFNB82. | ||
Sci Rep Deletion of Brg1 causes abnormal hair cell planer polarity, hair cell anchorage, and scar formation in mouse cochlea. | ||
Mol Biol Cell NuMA localization, stability, and function in spindle orientation involve 4.1 and Cdk1 interactions. | ||
Genes Chromosomes Cancer Critical roles of LGN/GPSM2 phosphorylation by PBK/TOPK in cell division of breast cancer cells.
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