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GS143

GS-143 是选择性的IκBα泛素化抑制剂，抑制 SCFβTrCP1介导的IκBα泛素化作用，IC50=5.2 μM。GS143 抑制NF-κB 的活化和靶基因的转录，并且不抑制蛋白酶体的特性，并具有抗哮喘作用。

CAS号

916232-21-8

分子式

C28H19FN2O4

主要靶点

NF-κB|IκB/IKK|E1/E2/E3 Enzyme

仅限科研使用

Cat No : CM04713

Print datasheet

Synonyms

GS-143|GS 143

验证数据展示

  • CAS No.: 916232-21-8

    GS143
    CAS#: 916232-21-8

产品信息

GS143 is a selec-tive IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 sup-presses NF-κB acti-va-tion and tran-scrip-tion of tar-get genes and does not inhibit proteasome activity. GS143 has anti-asthma effect

CAS号 916232-21-8
分子式 C28H19FN2O4
主要靶点 NF-κB|IκB/IKK|E1/E2/E3 Enzyme
主要通路 NF-κB信号通路|泛素化
分子量 466.46
纯度 99.72%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 GS-143|GS 143

靶点活性

IκBα phosphorylation:5.2 μM

溶解度

DMSO:40 mg/mL (85.75 mM),Sonification is recommended.

参考文献

1.Rashmi BS, Gayathri D. Molecular characterization of gluten hydrolysing Bacillus sp. and their efficacy and biotherapeutic potential as probiotics using Caco-2 cell line. J Appl Microbiol. 2017 Sep;123(3):759-772. doi: 10.1111/jam.13517. Epub 2017 Aug 4. PubMed PMID: 28637081.
2.Chen S, Wei YJ, Chen MM, Zhang ZT. Bilateral treatment: a strategy for enhancing the mechanical strength of machinable veneers. Dent Mater. 2010 Oct;26(10):961-7. doi: 10.1016/j.dental.2010.05.011. Epub 2010 Jul 23. PubMed PMID: 20655583.
3.Hirose K, Wakashin H, Oki M, Kagami S, Suto A, Ikeda K, Watanabe N, Iwamoto I, Furuichi Y, Nakajima H. GS143, an IkappaB ubiquitination inhibitor, inhibits allergic airway inflammation in mice. Biochem Biophys Res Commun. 2008 Sep 26;374(3):507-11. doi: 10.1016/j.bbrc.2008.07.072. Epub 2008 Jul 24. PubMed PMID: 18656449.
4.Nakajima H, Fujiwara H, Furuichi Y, Tanaka K, Shimbara N. A novel small-molecule inhibitor of NF-kappaB signaling. Biochem Biophys Res Commun. 2008 Apr 18;368(4):1007-13. doi: 10.1016/j.bbrc.2008.01.166. Epub 2008 Feb 12. PubMed PMID: 18275844.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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