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GSK-114

GSK 114 是口服有活性的、高选择性的TNNI3K 抑制剂 (IC50= 25 nM)。其中TNNI3K (又称 CARK) 是酪氨酸样激酶家族的成员，选择性在心脏组织中表达。它对 TNNI3K 的选择性是 B-Raf 激酶的 40 倍 (IC50= 1 µM)。

CAS号

1301761-96-5

分子式

C19H23N5O4S

主要靶点

Others

仅限科研使用

Cat No : CM06692

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Synonyms

验证数据展示

  • CAS No.: 1301761-96-5

    GSK-114
    CAS#: 1301761-96-5

产品信息

GSK-114 is a selective inhibitor of TNNI3 interacting kinase (TNNI3K) with an IC50 of 25 nM, 40-fold significant bias for TNNI3K compared to B-Raf with an IC50 of 1000 nM, so GSK-114 has excellent Broad-spectrum kinase selectivity and sufficient oral exposure enable use in cellular and in vivo studies.

CAS号 1301761-96-5
分子式 C19H23N5O4S
主要靶点 Others
主要通路 其他
分子量 417.48
纯度 98.03%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

靶点活性

TNNI3K:25 nM

溶解度

DMSO:5.5 mg/mL (13.17 mM),Need ultrasound

参考文献

1.Brian G. Lawhorna, Joanne Philpa, et al. GSK114: A selective inhibitor for elucidating the biological role of TNNI3K. Bioorganic & Medicinal Chemistry Letters. Volume 26, Issue 14, 15 July 2016, Pages 3355-3358

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