验证数据展示
Mouse monoclonal antibodies of IgA isotype can be detected with "anti-mouse IgG (H+L)" secondary antibodies.
产品信息
66280-1-PBS targets Gelsolin in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.
Tested Applications | WB, IHC, Indirect ELISA Application Description |
Tested Reactivity | human |
Immunogen | Gelsolin fusion protein Ag17916 种属同源性预测 |
Host / Isotype | Mouse / IgA |
Class | Monoclonal |
Type | Antibody |
Full Name | gelsolin (amyloidosis, Finnish type) |
Synonyms | Actin depolymerizing factor, ADF, AGEL, Brevin, Gelsolin, GSN |
Calculated Molecular Weight | 782 aa, 86 kDa |
Observed Molecular Weight | 80-83 kDa |
GenBank Accession Number | BC026033 |
Gene Symbol | Gelsolin |
Gene ID (NCBI) | 2934 |
RRID | AB_2881663 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Thiophilic affinity chromatograph |
UNIPROT ID | P06396 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Gelsolin (GSN) is an actin binding protein that regulates actin-severing/depolymerizing in a calcium dependent manner, and acts as a multifunctional regulator for cell metabolism and survival. Gelsolin exists in two isoforms: a cytoplasmic gelsolin (cGSN; 80-90 kDa) and a plasma gelsolin (pGSN; 93 kDa), differing at N terminal residues. Decreased levels of pGSN are strongly associated with human diseases, such as, acute liver injury, major trauma, myocardial infarction, inflammation, lung injury, rheumatoid arthritis, hemodialysis, multiple sclerosis, Alzheimer's disease.