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Geraniin

Geraniin 是一种肿瘤坏死因子α释放抑制剂，其IC50值为 43 μM，具有抗肿瘤、抗炎和抗高血糖活性。

CAS号

60976-49-0

分子式

C41H28O27

主要靶点

Antioxidant|TNF

仅限科研使用

Cat No : CM05862

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Synonyms

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  • CAS No.: 60976-49-0

    Geraniin
    CAS#: 60976-49-0

产品信息

1. Geraniin has a protective effect against OVX-induced rat osteoporosis. 2. Geraniin has cytotoxic activity towards cancer cells in vitro and in vivo. 3. Geraniin exerts inhibitory effects on osteoclast differentiation in vitro and suppresses Ti particle-induced osteolysis in vivo, is a potential natural compound for the treatment of wear particle induced osteolysis in prostheses failure. 4. Geraniin has anti-oxidant activity, induces Nrf2-mediated expression of antioxidant enzymes HO-1 and NQO1, presumably via PI3K/AKT and ERK1/2 signaling pathways, thereby protecting cells from H2O2-induced oxidative cell death. 5. Geraniin presents radioprotective effects by regulating DNA damage on splenocytes, exerting immunostimulatory capacities and inhibiting apoptosis of radiosensitive immune cells and jejunal crypt cells.

CAS号 60976-49-0
分子式 C41H28O27
主要靶点 Antioxidant|TNF
主要通路 凋亡|氧化还原
分子量 952.64
纯度 99.92%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

靶点活性

TNF-α:43 μM.

溶解度

Pyridine, Methanol, etc.:Soluble,Ethanol:Soluble,DMSO:91 mg/mL(95.5 mM)

参考文献

1.Geraniin exerts cytoprotective effect against cellular oxidative stress by upregulation of Nrf2-mediated antioxidant enzyme expression via PI3K/AKT and ERK1/2 pathway[J]. Biochimica et Biophysica Acta (BBA) - General Subjects, 2015, 1850(9):1751-1761.

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